Beta estrogen receptor knockout (BERKO) mice present attenuated hippocampal CA1 long-term potentiation and related memory deficits in contextual fear conditioning
Beta estrogen receptor knockout (BERKO) mice present attenuated hippocampal CA1 long-term potentiation and related memory deficits in contextual fear conditioning
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DOI：
10.1016/j.bbr.2005.05.011
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发表时间：
2005-10-14
影响因子：
2.7
通讯作者：
Arias, R
中科院分区：
文献类型：
--
作者：
Day, M;Sung, A;Arias, R
雌激素对海马突触可塑性有显着影响。我们证明，雄性和雌性 3 个月大的 β 雌激素受体敲除 (BERKO) 小鼠在海马介导的恐惧调节范式中表现出严重的记忆障碍。随后，对行为幼稚的雌性 BERKO 小鼠制备的海马切片进行电生理学检查。与来自年龄匹配的野生型对照的切片相比，这些细胞被发现在输入-输出曲线和 CA1 区长时程增强的表达方面都具有强大的突触缺陷。该报告首次提供了 BERKO 小鼠海马突触可塑性和记忆缺陷的具体证据。 (c) 2005 年 Elsevier B.V. 出版
Estrogen has marked effects on hippocampal synaptic plasticity. We demonstrate that male and female 3-month-old beta estrogen receptor knockout (BERKO) mice show profound memory impairment in a hippocampus-mediated fear-conditioning paradigm. Subsequently, hippocampal slices prepared from behaviorally naive female BERKO mice were examined electrophysiologically. These were found to have robust synaptic deficits, compared to slices from age-matched wild type controls, both in terms of their input-output curves and their expression of long-term-potentiation in area CA1. This report provides the first concrete evidence of significant hippocampal synaptic plasticity and memory deficits in the BERKO mouse. (c) 2005 Published by Elsevier B.V.