Bacterial Autophagy: Offense and Defense at the Host-Pathogen Interface.
Bacterial Autophagy: Offense and Defense at the Host-Pathogen Interface.
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DOI：
10.1016/j.jcmgh.2017.05.002
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发表时间：
2017-09
影响因子：
7.2
通讯作者：
Casanova JE
中科院分区：
文献类型：
--
作者：
Casanova JE
自噬是一种基本的细胞过程，用于胞浆成分和受损细胞器的周转和循环。自噬最初是对细胞应激的一种反应，现在公认的是自噬也被用作一种防御机制，以对抗细胞内病原体对宿主细胞的感染。然而，尽管这种防御策略确实限制了大多数病原体在其宿主细胞内的增殖，但成功的病原体已经进化出了颠覆或绕过自噬反应的对策。在这篇综述中，我们讨论了一些这些病原体用来逃避自噬的机制，特别是肠炎沙门氏菌血清鼠伤寒沙门氏菌，它一直是研究最广泛的例子。我们还将讨论细菌自噬对更广泛的先天性免疫反应的影响。
Autophagy is a fundamental cellular process used for the turnover and recycling of cytosolic components and damaged organelles. Originally characterized as a response to cellular stress, it now is well established that autophagy also is used as a defensive mechanism to combat the infection of host cells by intracellular pathogens. However, although this defensive strategy does limit the proliferation of most pathogens within their host cells, successful pathogens have evolved countermeasures that subvert or circumvent the autophagic response. In this review, we discuss the mechanisms used by a number of these pathogens to escape autophagy, with a particular focus on Salmonella enterica serovar Typhimurium, which has been the most extensively studied example. We also discuss the consequences of bacterial autophagy for the broader innate immune response.