Temporally massed CS presentations generate more fear extinction than spaced presentations
Temporally massed CS presentations generate more fear extinction than spaced presentations
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DOI：
10.1037/0097-7403.29.4.323
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发表时间：
2003-10-01
期刊：
影响因子：
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通讯作者：
Barad, M
中科院分区：
文献类型：
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作者：
Cain, CK;Blouin, AM;Barad, M
啮齿动物的恐惧条件反射模拟了兴奋性学习和人类焦虑的发病机制，而条件性恐惧的消除则是抑制性学习的范例和行为治疗的外显模型。许多研究支持习得的一般学习规则：时间间隔训练比大规模训练更有效。作者想知道这一规律是否适用于小鼠条件恐惧的消除。作者发现，短期和长期的恐惧消退在条件刺激（CS）的临时集中呈现中都更大。数据还表明，一旦CS演示足够多，足以启动或“诱导”消退学习，那么间隔后的CS演示更有效。
Rodent fear conditioning models both excitatory learning and the pathogenesis of human anxiety, whereas extinction of conditional fear is a paradigm of inhibitory learning and the explicit model for behavior therapy. Many studies support a general learning rule for acquisition: Temporally spaced training is more effective than massed training. The authors asked whether this rule applies to extinction of conditional fear in mice. The authors find that both short- and long-term fear extinction are greater with temporally massed presentations of the conditional stimulus (CS). The data also indicate that once CS presentations are sufficiently massed to initiate, or "induce," extinction learning, further CS presentations are more effective when spaced.