Phenotypic characteristics of asthma and morbidity are associated with distinct longitudinal changes in L-arginine metabolism.
Phenotypic characteristics of asthma and morbidity are associated with distinct longitudinal changes in L-arginine metabolism.
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DOI：
10.1136/bmjresp-2023-001683
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发表时间：
2023-06
影响因子：
4.1
通讯作者：
中科院分区：
文献类型：
--
作者：
L-精氨酸代谢组在哮喘中失调，尽管目前尚不清楚L-精氨酸代谢的纵向变化在哮喘表型中的差异以及与疾病结局的关系。确定表型特征与L-精氨酸代谢产物及其与哮喘发病率之间的纵向关系。这是一项前瞻性队列研究，321例哮喘患者每半年随访一次，持续18个月以上，评估血浆L-精氨酸代谢产物、哮喘控制、肺功能测定、生活质量和急性发作。使用自然对数转换代谢物浓度和比值。在校正模型中，不同哮喘表型的L-精氨酸代谢存在差异。体重指数的增加与不对称二甲基精氨酸（ADMA）的增加和L-瓜氨酸的消耗有关。Latinx通过谷胱甘肽酶与代谢增加相关，L-鸟氨酸、脯氨酸和L-鸟氨酸/L-瓜氨酸水平较高，并且发现与白色人种相比，L-精氨酸的可用性较高。关于哮喘结局，增加L-瓜氨酸与改善哮喘控制相关，增加L-精氨酸和L-精氨酸/ADMA与改善生活质量相关。12个月内L-精氨酸、L-精氨酸/ADMA、L-精氨酸/L-鸟氨酸和L-精氨酸利用指数的变异性增加与急性加重增加相关，OR 4.70（95% CI 1.35 - 16.37）、OR 8.69（95% CI 1.98 - 38.08）、OR 4.17（95% CI 1.40 - 12.41）和OR 4.95（95% CI 1.42 - 17.16）。我们的研究结果表明，L-精氨酸代谢与多种哮喘控制措施相关，并可能部分解释年龄，种族/民族和肥胖与哮喘结局之间的关系。
The L-arginine metabolome is dysregulated in asthma, though it is not understood how longitudinal changes in L-arginine metabolism differ among asthma phenotypes and relate to disease outcomes. To determine the longitudinal associations between phenotypic characteristics with L-arginine metabolites and their relationships with asthma morbidity. This is a prospective cohort study of 321 patients with asthma followed semiannually for over 18 months with assessments of plasma L-arginine metabolites, asthma control, spirometry, quality of life and exacerbations. Metabolite concentrations and ratios were transformed using the natural logarithm. There were many differences in L-arginine metabolism among asthma phenotypes in the adjusted models. Increasing body mass index was associated with increased asymmetric dimethylarginine (ADMA) and depleted L-citrulline. Latinx was associated with increased metabolism via arginase, with higher L-ornithine, proline and L-ornithine/L-citrulline levels, and was found to have higher L-arginine availability compared with white race. With respect to asthma outcomes, increasing L-citrulline was associated with improved asthma control and increasing L-arginine and L-arginine/ADMA were associated with improved quality of life. Increased variability in L-arginine, L-arginine/ADMA, L-arginine/L-ornithine and L-arginine availability index over 12 months were associated with increased exacerbations, OR 4.70 (95% CI 1.35 to 16.37), OR 8.69 (95% CI 1.98 to 38.08), OR 4.17 (95% CI 1.40 to 12.41) and OR 4.95 (95% CI 1.42 to 17.16), respectively. Our findings suggest that L-arginine metabolism is associated with multiple measures of asthma control and may explain, in part, the relationship between age, race/ethnicity and obesity with asthma outcomes.
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DOI：
10.1155/2013/714595
发表时间：
2013
期刊：
Journal of allergy
影响因子：
--
作者：
Holguin F
通讯作者：
Holguin F
影响因子：
3.8
作者：
Ladva CN;Golan R;Greenwald R;Yu T;Sarnat SE;Flanders WD;Uppal K;Walker DI;Tran V;Liang D;Jones DP;Sarnat JA
通讯作者：
Sarnat JA
影响因子：
14.2
作者：
Lugogo, Njira;Green, Cynthia L.;Kraft, Monica
通讯作者：
Kraft, Monica
影响因子：
3.9
作者：
Bollenbach, Alexander;Schutte, Aletta E.;Tsikas, Dimitrios
通讯作者：
Tsikas, Dimitrios
影响因子：
8
作者：
Liao, Shu-Yi;Showalter, Megan R.;Kenyon, Nicholas J.
通讯作者：
Kenyon, Nicholas J.