Thermochromism-induced temperature self-regulation and alternating photothermal nanohelix clusters for synergistic tumor chemo/photothermal therapy
Thermochromism-induced temperature self-regulation and alternating photothermal nanohelix clusters for synergistic tumor chemo/photothermal therapy
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热致变色诱导的温度自我调节和交替光热纳米螺旋簇用于协同肿瘤化疗/光热治疗
DOI：
10.1016/j.biomaterials.2018.10.008
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发表时间：
2019-01-01
期刊：
影响因子：
14
通讯作者：
Wu, Daocheng
中科院分区：
文献类型：
--
作者：
Tang, Peng;Liu, Yongchun;Wu, Daocheng
为了改善化疗和光热疗法（PTT）的固有缺陷，我们在分子动力学模拟的指导下，将碘（I-2）通过疏水相互作用负载到乙酰化直链淀粉（AA）的螺旋空腔中，设计了一种基于ILAA NHC的新型热致变色诱导温度自调节和交替光热系统。ILAA NHC通过其独特的可逆热致变色性进行多功能光热转换。照射后，I-2逐渐释放，ILAA NHC变为无色。然后，激光深深穿透到组织中进行深层加热，并且由于I-2重新加载到ILAA NHC中，ILAA NHC的颜色可以通过可逆热致变色恢复。当重复该过程时，温度可以控制在一定范围内。这种交替的光热转换显著提高了PTT的效果。同时，I-2还有效地发挥化疗和PTT的双重作用。结果表明，ILAA NHC的光热深度是其他常用光热剂（PTA）的2.1倍，并且照射区域具有较低的表面温度。体外和体内实验均为ILAA NHC提供了具有协同化疗/PTT的优异综合抗肿瘤作用，表明肿瘤化疗/PTT的多功能潜力。
To improve the inherent defects of chemotherapy and photothermal therapy (PTT), we design a novel thermochromism-induced temperature self-regulation and alternating photothermal system based on iodine (I-2)-loaded acetylated amylose nanohelix clusters (ILAA NHCs) under the guidance of molecular dynamic simulation in which I-2 is loaded into the helical cavity of acetylated amylose (AA) by hydrophobic interaction. ILAA NHCs perform versatile photothermal conversion through their unique reversible thermochromism. Upon irradiation, I-2 is gradually released and the ILAA NHCs turn into colorless. The laser is then penetrated deeply into the tissue for deep-seated heating, and the ILAA NHCs' color can be recovered by reversible thermochromism because of I-2 reloading into the ILAA NHCs. When the process is repeated, the temperature can be controlled in a certain range. This alternating light-to-heat conversion significantly improve the effect of PTT. Meanwhile, I-2 efficiently acts dual functions of chemotherapy and PTT. Results show that the photothermal depth by ILAA NHCs is 2.1-fold than other common photothermal agents (PTAs), and the irradiated region exhibits a lower surface temperature. In vitro and in vivo experiments both provide ILAA NHCs an excellent comprehensive antitumor effect with synergistic chemo/PTT, indicating versatile potential for tumor chemo/PTT.