Sex steroids and bone mass. A study of changes about the time of menopause.
Sex steroids and bone mass. A study of changes about the time of menopause.
复制标题
性类固醇和骨量。
DOI：
10.1172/jci113201
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Johnston,CC
中科院分区：
文献类型：
--
作者：
Slemenda,C;Hui,SL;Longcope,C;Johnston,CC
为探讨骨质流失与性类固醇激素的关系，对84名绝经期和绝经后妇女进行了为期3年的4个月的研究。在每次访问时，测量的骨量在中段和远端的半径，类固醇，促性腺激素，骨钙蛋白（BGP）。在围绝经期晚期和绝经后组中，每年约有1%的骨丢失，而围绝经期早期组没有骨丢失。平均血清雌激素和骨钙素浓度预测骨丢失率。BGP与骨丢失率（r = -0.45）和平均雌激素浓度（r = -0.40）呈负相关。多元回归分析显示雌激素浓度是骨量随时间变化斜率的强独立预测因子。当BGP浓度添加到模型中时，雌激素的显著性降低，表明雌激素效应的一部分是通过对骨重建速率的影响介导的。
To examine the relationships between bone loss and sex steroids, 84 peri- and postmenopausal women were studied at 4-mo intervals for 3 yr. At each visit, measurements were made of bone mass at the midshaft and distal radius, of steroids, of gonadotropins, and of bone gla protein (BGP). Bone loss was approximately 1% per yr among late perimenopausal and postmenopausal groups, whereas the early perimenopausal group lost no bone. Mean serum estrogen and BGP concentrations predicted rates of bone loss. BGP was negatively correlated with the rate of bone loss (r = -0.45) and with mean estrogen concentrations (r = -0.40). Multivariate regressions showed estrogen concentrations to be strong independent predictors of the slope of bone mass over time. When BGP concentrations were added to the models, the significance of estrogen was reduced, suggesting that a portion of the estrogen effect was mediated through effects on rates of bone remodelling.
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