Elevated TNF-α and LDH without parathormone disturbance is associated with diffuse osteolytic lesions in leukemic transformation of myelofibrosis
Elevated TNF-α and LDH without parathormone disturbance is associated with diffuse osteolytic lesions in leukemic transformation of myelofibrosis
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DOI：
10.1016/j.prp.2007.09.001
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发表时间：
2008-01-01
影响因子：
2.8
通讯作者：
Colovic, Milica
中科院分区：
文献类型：
--
作者：
Jurisic, Vladimir;Terzic, Tatjana;Colovic, Milica
骨髓纤维化是一种克隆性骨髓增生性疾病，其特征在于脾肿大、骨髓中胶原蛋白异常沉积、髓外造血、红细胞增多和白细胞成红细胞血涂片。纤维化的发展和维持由几种细胞因子的复杂网络介导，包括肿瘤坏死因子-α（TNF-α）。骨质疏松是骨髓纤维化中最常见的骨变化。基于此，我们提出了一个非典型的情况下，白血病转化骨髓纤维化与弥漫性溶骨性病变和极高的TNF-α和乳酸脱氢酶（LDH）。甲状旁腺素未受干扰。(C)2007年爱思唯尔有限公司。All rights reserved.
Myelofibrosis is a clonal myeloproliferative disorder characterized by splenomegaly, abnormal deposition of collagen in the bone marrow, extramedullary hematopoiesis, dacriocytosis, and leukoerythroblastic blood smear. Development and maintenance or fibrosis are mediated by a complex network of several cytokines, including tumor necrosis factor-alpha (TNF-alpha). Osteosclerosis is the most frequently observed bone change in myelofibrosis. Based on this, we present an atypical case of leukemic transformation in myelofibrosis associated with diffuse osteolytic lesions and extremely elevated TNF-alpha and lactate dehydrogenase (LDH). Parathormone was not disturbed. (C) 2007 Elsevier GmbH. All rights reserved.