Carbonated hydroxyapatite as bone substitute
Carbonated hydroxyapatite as bone substitute
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DOI：
10.1016/s0955-2219(03)00304-2
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发表时间：
2003-01-01
影响因子：
5.7
通讯作者：
Tampieri, A
中科院分区：
文献类型：
--
作者：
Landi, E;Celotti, G;Tampieri, A
以四水硝酸钙、磷酸氢二铵和碳酸氢钠为原料合成了B-碳酸磷灰石（CHA）粉体。粉末的相纯度，化学计量，形态，比表面积和粒度分布方面进行了充分的表征。通过热分析评价了粉末在空气和CO2气氛中的热稳定性。CHA粉末的水基悬浮液的电声分析用于确定浆料的稳定性。通过用适当的粉末浆料浸渍纤维素海绵并优化随后的烧结来制备CHA的多孔体。烧结样品的特征在于相纯度和碳酸盐含量，微观结构和孔径分布。还评估了压缩强度，结果为6.0 +/-0.5MPa。新西兰白色兔体内试验的初步结果显示，与用作对照的HA样品相比，CHA植入物具有良好的生物相容性和骨整合性，具有更高的骨传导性能和更早的生物吸收。(C)2003年由Elsevier Ltd.出版
B-carbonateapatite (CHA) powder was synthesized starting from calcium nitrate tetrahydrate, diammonium hydrogen phosphate and sodium hydrogen carbonate. The powder was fully characterized in terms of phase purity, stoichiometry, morphology, specific surface area and particle size distribution. The thermal stability of the powder in air and CO2 atmosphere also was evaluated by thermal analysis. Electroacoustic analysis of the water based suspension of the CHA powder was used to determine the stability of the slurry. Porous bodies of CHA were prepared by impregnation of cellulose sponges with a proper Slurry of the powder and optimizing the subsequent sintering. The fired samples were characterized in terms of phase purity and carbonate content, microstructure and pore size distribution. The compressive strength also was evaluated, resulting in 6.0 +/- 0.5 MPa. First results of in vivo tests on New Zealand White rabbits showed good biocompatibility and osteointegration of the CHA implant, with higher osteoconductive properties and earlier bioresorption, compared to HA samples, used as control. (C) 2003 Published by Elsevier Ltd.