Theory of Transport-Induced-Charge Electroosmotic Pumping toward Alternating Current Resistive Pulse Sensing
Theory of Transport-Induced-Charge Electroosmotic Pumping toward Alternating Current Resistive Pulse Sensing
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DOI：
10.1021/acssensors.8b00635
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发表时间：
2018-11-01
期刊：
影响因子：
8.9
通讯作者：
Daiguji, Hirofumi
中科院分区：
文献类型：
--
作者：
Hsu, Wei-Lun;Hwang, Junho;Daiguji, Hirofumi
在这项工作中，我们研究了传输感应电荷电渗透对交流阻性脉冲传感的应用，为下一代生物医学应用奠定了基础。传输诱导电荷电渗透是一种新型的电动力学现象，它是由于超薄纳米孔中的盐浓度梯度与电场的协同作用而发生的。除了传统的双电层电渗流的流动行为受表面电荷的影响外，研究发现，输运诱导电荷电渗流的行为与表面电荷量无关，但可以受体盐浓度偏压的线性调节。电场的反转同时使感应电荷反转，从而在周期性交变电场的作用下建立单向流动。这种独特的现象允许水和纳米颗粒连续泵送通过二维材料纳米孔，尽管电场发生了逆转。基于这一机理，我们提出了一种二维纳米孔系统中交流阻性脉冲传感的理论原型。
In this work, we study transport-induced-charge electroosmosis toward alternating current resistive pulse sensing for the next generation of biomedical applications. Transport-induced-charge electroosmosis, being a new class of electrokinetic phenomenon, occurs as a salt concentration gradient works in synergy with an electric field in ultrathin nanopores. Apart from the conventional electric double layer-governed electroosmotic flow in which the flow behavior is subject to the surface charge, it is found that the transport-induced-charge electroosmotic flow behaves independently of surface charge magnitude but can be linearly regulated by the bulk salt concentration bias. The reversal of the electric field simultaneously inverses the induced charge allowing the establishment of a unidirectional flow under the application of a periodic alternating current field. This unique phenomenon permits continuous water and nanoparticles pumping through a two-dimensional material nanopore in spite of the reversal of the electric field. Built upon this mechanism, we propose a theoretical prototype of alternating current resistive pulse sensing in a two-dimensional nanopore system.