Dorsal anterior cingulate function in posttraumatic stress disorder.
Dorsal anterior cingulate function in posttraumatic stress disorder.
复制标题
创伤后应激障碍中的背侧前扣带回功能。
DOI：
10.1002/jts.20231
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发表时间：
2007
影响因子：
3.3
通讯作者：
Rauch,ScottL
中科院分区：
文献类型：
--
作者：
Shin,LisaM;Bush,George;Whalen,PaulJ;Handwerger,Kathryn;Cannistraro,PaulA;Wright,ChristopherI;Martis,Brian;Macklin,MichaelL;Lasko,NatashaB;Orr,ScottP;Pitman,RogerK;Rauch,ScottL
先前的神经影像学研究表明，创伤后应激障碍（PTSD）患者的前扣带皮层（ACC）功能减弱，这些发现大多发生在前/亚属ACC。本研究探讨背侧ACC （dACC）功能是否也在PTSD中减弱。作者采用功能磁共振成像技术研究了计数Stroop执行过程中dACC的功能。13名患有创伤后应激障碍的男性和13名没有创伤后应激障碍的创伤暴露男性参与了研究。在干扰中性的比较中，两组均表现出反应时间增加和dACC激活。这些结果表明，PTSD患者的dACC功能在执行非情绪性任务时并未减弱。事实上，统计上的趋势与此相反。这些发现将有助于更好地描述这种疾病的功能性大脑异常。十多年来，研究人员一直使用神经成像技术来研究创伤后应激障碍（PTSD）患者的大脑功能。这项研究的一个直接目标是确定在这种疾病中大脑区域或网络的功能是否异常。关于PTSD患者大脑区域的结构或功能的信息可能为诊断、危险因素的识别和治疗反应的预测提供潜在的信息。创伤后应激障碍中最一致的功能神经影像学发现之一是内侧前额皮质的激活相对减少，包括前扣带皮层（ACC）和内侧额回。这些脑区涉及多个领域，包括情绪信息的处理和安全信号信息的保留（Bush, Luu, & Posner, 2000; Milad & Quirk, 2002; Quirk, Russo, Barron, & Lebron, 2000; Vogt, Finch, & Olson, 1992）。创伤后应激障碍的前扣带皮层激活减少或无法激活已在以下方面得到证实：呈现创伤性叙述（Bremner， Narayan等，1999;Britton, Phan, Taylor, Fig, & Liberzon, 2005； Lanius等，2001；Lindauer等，2004；Shin等，1999）、消极的非创伤性刺激（Lanius等，2003;Phan, Britton, Taylor, Fig, & Liberzon, 2006）、战斗图片和/或声音(Bremner， Staib等，1999；Yang, Wu, Hsu, & Ker, 2004)和恐惧的面部表情（Shin et al., 2005; Williams et al., 2006）。在恐惧条件反射后的消退过程中，以及在听觉连续表演过程中，PTSD中ACC的激活也相对减少
Previous neuroimaging research has shown diminished anterior cingulate cortex (ACC) function in posttraumatic stress disorder (PTSD), with most of these findings occurring in pregenual/subgenual ACC. This study investigates whether dorsal ACC (dACC) function is also diminished in PTSD. The authors used functional magnetic resonance imaging to study dACC function during the performance of the counting Stroop. Thirteen men with PTSD and 13 trauma-exposed men without PTSD participated. In the interference-neutral comparison, both groups showed response time increases and dACC activations. These results suggest that dACC function in PTSD is not diminished during the performance of this nonemotional task. In fact, there were statistical trends in the opposite direction. These findings will help to better characterize functional brain abnormalities in this disorder.For over a decade, researchers have used neuroimaging techniques to study brain function in posttraumatic stress disorder (PTSD). An immediate goal of this research is to determine whether brain regions or networks function abnormally in this disorder. Information about the structure or function of brain regions in PTSD could potentially inform diagnosis, the identification of risk factors, and the prediction of treatment response. One of the most consistent functional neuroimaging findings in PTSD has been that of relatively diminished activation in the medial prefrontal cortex, including the anterior cingulate cortex (ACC) and the medial frontal gyrus. These brain regions are involved in a variety of domains, including the processing of emotional information and the retention of information about safety signals (Bush, Luu, & Posner, 2000; Milad & Quirk, 2002; Quirk, Russo, Barron, & Lebron, 2000; Vogt, Finch, & Olson, 1992). Decreased activation or failure to activate the ACC in PTSD has been demonstrated during the presentation of traumatic narratives (Bremner, Narayan et al., 1999; Britton, Phan, Taylor, Fig, & Liberzon, 2005; Lanius et al., 2001; Lindauer et al., 2004; Shin et al., 1999), negative nontraumatic stimuli (Lanius et al., 2003; Phan, Britton, Taylor, Fig, & Liberzon, 2006), combat pictures and/or sounds (Bremner, Staib et al., 1999; Yang, Wu, Hsu, & Ker, 2004), and fearful facial expressions (Shin et al., 2005; Williams et al., 2006). Relatively diminished activation of the ACC in PTSD has also been shown during extinction after fear conditioning (Bremner et al., 2005), as well as during auditory continuous performance