Progression of defects in the central 10-degree visual field of patients with retinitis pigmentosa and choroideremia
Progression of defects in the central 10-degree visual field of patients with retinitis pigmentosa and choroideremia
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DOI：
10.1016/s0002-9394(98)00408-5
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发表时间：
1999-04-01
影响因子：
4.2
通讯作者：
Tsukahara, S
中科院分区：
文献类型：
--
作者：
Hirakawa, H;Iijima, H;Tsukahara, S
目得：通过对平均偏差进行单变量线性回归，确定视网膜色素变性和无脉络膜症患者中央10度视野缺损的进展情况，方法：在一项回顾性研究中，对视网膜色素变性和无脉络膜症患者的中央10度视野自动静态视野检查结果进行了审查，对每只眼睛进行平均偏差的单变量线性回归，这些眼睛除了在3.5年或更长时间内的先前静态视野经验之外，还具有至少5次测试的视野数据。来自16名患者的30只眼睛的数据符合资格要求;平均视野数为5.8（范围，5 - 10），平均随访期为64个月（范围，42至97个月），如果回归系数为负且与零有显著差异，则将眼睛分类为进行性，P值小于0.05，结果：在14例双眼均符合单变量线性回归分析条件的患者中，4例患者的双眼、5例患者的单眼和5例患者的双眼均显示统计学显著性进展。两名患者中只有一只眼睛符合研究条件，其中一名患者的眼睛出现了显著进展。总体而言，30只眼中有14只眼（47%）在平均偏差方面显示出统计学显著进展。没有眼睛表现出显着improvement.Conclusions：自动静态视野的中央10度视野测量约一年一次或两次，证明了疾病的进展性质与使用单变量线性回归的平均偏差在47%的眼睛视网膜色素变性和脉络膜无色素在随访期间的3.5年或更长时间。这些结果可能有助于了解疾病的临床过程和咨询患者。(Am J Ophthalmol 1999;127：436-442，（C）1999，Elsevier Science Inc.版权所有© 2016
PURPOSE: To determine the progression of defects in the central 10-degree visual field in patients with retinitis pigmentosa and choroideremia by means of univariate linear regression with respect to the mean deviation,METHODS: In a retrospective study, results of automated static perimetry in the central 10-degree visual field were reviewed for patients with retinitis pigmentosa and choroideremia, Univariate linear regression of mean deviation was undertaken for each eye that had field data from at least five tests in addition to the prior static perimetric experience during a period of 3.5 years or more, Data from 30 eyes of 16 patients fulfilled eligibility requirements; the moan number of fields was 5.8 (range, five to 10) and the mean follow-up period was 64 months (range, 42 to 97 months), Eyes were classified as progressive if the regression coefficient was negative and significantly different from zero, with a P value of less than,05,RESULTS: Among 14 patients in whom both eyes were eligible for univariate linear regression analysis, a statistically significant progression was demonstrated in both eyes in four patients, only in one eye in five patients, and in neither eye in five patients. One of two patients, in whom only one eye was eligible for the study, showed significant progression in the eye. Overall, 14 (47%) of 30 eyes showed statistically significant progression with respect to the mean deviation. No eye showed significant improvement.CONCLUSIONS: Automated static perimetry of the central 10 degree visual field measured approximately once or twice a year demonstrated the progressive nature of the disease with the use of univariate linear regression of mean deviation in 47% of eyes with retinitis pigmentosa and choroideremia during the follow-up period of 3.5 years or more. These results may be useful in understanding the clinical course of the diseases and counseling patients. (Am J Ophthalmol 1999;127: 436-442, (C) 1999 by Elsevier Science Inc. All rights reserved.).