Decreased plasma adiponectin concentration in patients with essential hypertension
Decreased plasma adiponectin concentration in patients with essential hypertension
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DOI：
10.1016/s0895-7061(02)03197-7
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发表时间：
2003-01-01
影响因子：
3.2
通讯作者：
Matsuzawa, Y
中科院分区：
文献类型：
--
作者：
Adamczak, M;Wiecek, A;Matsuzawa, Y
脂肪细胞分泌的几种生物活性物质被认为是参与肥胖相关的高血压。为探讨脂联素在原发性高血压中的作用，对33例原发性高血压（EH）患者的血浆脂联素水平进行了测定（12名女性，21名男性）和33名体重指数匹配的血压正常的健康受试者（NHS）EHP组血浆脂联素浓度显著低于NHS组（分别为9.1 ± 4.5和13.7 ± 5.2 μ g/mL）。在所有受试者中，血浆脂联素浓度与平均血压、收缩压和舒张压呈显著负相关，表明脂联素与原发性高血压的临床病程有关。
Adipocytes secrete several biologically active substances that are presumed to be involved in obesity-related hypertension. There are no reports that deal with the relationship between plasma adiponectin concentration and blood pressure (BP).To evaluate the role of adiponectin in essential hypertension 33 patients with essential hypertensive (EHP) (12 women, 21 men) and 33 body mass index-matched normotensive healthy subjects (NHS) (13 women, 20 men) were studied.In EHP plasma adiponectin concentration was significantly lower than in NHS (9.1 +/- 4.5 v 13.7 +/- 5.2 mug/mL, respectively). In all subjects a significant negative correlation was found between plasma adiponectin concentration and mean, systolic, and diastolic BP, suggesting that adiponectin contributes to the clinical course of essential hypertension.