Early response of lungs to low levels of nitrogen dioxide. Light and electron microscopy.
Early response of lungs to low levels of nitrogen dioxide. Light and electron microscopy.
复制标题
肺部对低水平二氧化氮的早期反应。
DOI：
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发表时间：
1972
期刊：
影响因子：
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通讯作者：
M. J. Evans
中科院分区：
文献类型：
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作者：
R. J. Stephens;G. Freeman;M. J. Evans
暴露于二氧化氮的大鼠的肺部在暴露于 17 ppm 的二氧化氮的最初 72 小时内发生显着变化。这些变化出现在终末细支气管水平的焦点区域：纤毛丧失；组织增厚；当整个 1 型细胞脱落，使基底膜暴露在空气中时，邻近终末细支气管的泡膜内衬上皮细胞受到损伤；在连续暴露 24 至 48 小时之间，这些区域会被一种低立方细胞类型修复，这种细胞能够耐受 NO2 并增厚气血屏障；最终形成晶体并中断纤毛发生。 2 ppm 的变化包括纤毛损失、终末细支气管上皮细胞肥大和局灶性增生，并且在连续暴露 21 天后“明显”恢复正常。
Significant changes in the lungs of rats exposed to nitrogen dioxide occur during the first 72 hours in animals exposed to 17 ppm. These changes appear in focal areas at the level of the terminal bronchiole: loss of cilia; thickening of tissue; injury to the epithelium lining the adveoli adjacent to the terminal bronchioles, when whole type 1 cells slough away leaving the basement membrane exposed to the air; between 24 and 48 hours of continuous exposure, these areas are repaired with a low cuboidal cell type that tolerates NO2 and thickens the air-blood barrier; and eventual formation of crystalloids and interruption of ciliogenesis. Changes at 2 ppm include loss of cilia, hypertrophy and focal hyperplasia in the epithelium of the terminal bronchiole, and “apparent” return to normal after 21 days of continuous exposure.