Design Strategies and Applications of Biomaterials and Devices for Hernia Repair.
Design Strategies and Applications of Biomaterials and Devices for Hernia Repair.
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DOI：
10.1016/j.bioactmat.2016.05.002
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发表时间：
2016-09
影响因子：
18.9
通讯作者：
Yang J
中科院分区：
文献类型：
--
作者：
Kalaba S;Gerhard E;Winder JS;Pauli EM;Haluck RS;Yang J
疝修补术是世界上最常见的外科手术之一，全球市场价值数十亿美元。植入物的设计仍然是成功修复和预防复发腹股沟的关键挑战，尽管取得了重大进展，但没有适用于每一种手术的理想网状物。本文从疾病的解剖学和疝气的分类入手，总结了人造腹股沟修补术向成功修补的演变。接下来，对种植体设计的主要里程碑进行了讨论。描述了常见的并发症和将这些不良影响降至最低的策略，然后详细描述了成功修复所必需的植入物特征。最后，对现有的植入物进行了分类，并阐明了它们的优点和局限性，包括不可吸收和可吸收(合成和生物衍生)假体、复合假体和涂层假体。本文不仅综述了疝修补术的研究现状，而且提出了利用新材料和制造方法改进疝修补术的未来研究方向。该综述总结了外科技术和人工网片设计的演变，以期获得成功的疝修补术。它还展望了生物材料和疝气网状物的未来发展战略，以柠檬酸盐为基础的可生物降解光致发光聚合物(BPLP)涂层策略为例，可能解决网状物引发的严重慢性炎症和组织粘连等常见问题。疝修补术是世界上最常见的外科手术之一，全球市场价值数十亿美元。本文从疾病的解剖学和疝气的分类入手，总结了外科技术和修复体设计向成功修补腹股沟的演变。它还提出了改进腹股沟修补术的未来研究方向。
Hernia repair is one of the most commonly performed surgical procedures worldwide, with a multi-billion dollar global market. Implant design remains a critical challenge for the successful repair and prevention of recurrent hernias, and despite significant progress, there is no ideal mesh for every surgery. This review summarizes the evolution of prostheses design toward successful hernia repair beginning with a description of the anatomy of the disease and the classifications of hernias. Next, the major milestones in implant design are discussed. Commonly encountered complications and strategies to minimize these adverse effects are described, followed by a thorough description of the implant characteristics necessary for successful repair. Finally, available implants are categorized and their advantages and limitations are elucidated, including non-absorbable and absorbable (synthetic and biologically derived) prostheses, composite prostheses, and coated prostheses. This review not only summarizes the state of the art in hernia repair, but also suggests future research directions toward improved hernia repair utilizing novel materials and fabrication methods. This review summarizes the evolution of surgical techniques and prosthetic mesh design toward successful hernia repair. It also outlooks strategies for future development of biomaterials and hernia meshes exemplified by the citrate-based biodegradable photoluminescent polymer (BPLP) coating strategy for possibly addressing the common problems of mesh-triggered severe chronic inflammation and tissue adhesion. Hernia repair is one of the most commonly performed surgical procedures worldwide, with a multi-billion dollar global market. This review summarizes the evolution of surgical techniques and prostheses design toward successful hernia repair beginning with a description of the anatomy of the disease and the classifications of hernias. It also suggests future research directions toward improved hernia repair.