Comparison of Ki-67, cyclin E, and p63 in benign and malignant human pleomorphic adenoma
Comparison of Ki-67, cyclin E, and p63 in benign and malignant human pleomorphic adenoma
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Ki-67、cyclin E、p63在良恶性人多形性腺瘤中的比较
DOI：
10.1016/j.oooo.2012.01.013
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发表时间：
2012-05-01
影响因子：
2.9
通讯作者：
Feng, Xiaojie
中科院分区：
文献类型：
--
作者：
Zhu, Xiaojie;Zhang, Jiali;Feng, Xiaojie
Objective.采用一组细胞增殖相关分子标记物检测良性多形性腺瘤（PA）和癌性多形性腺瘤（CXPA）增殖活性的差异。选择了70个样本，包括53个PA，10个非侵入性和7个广泛侵入性（WI）CXPA。免疫组化法检测Ki-67、cyclin E、p63蛋白的表达。WI CXPA的平均Ki-67标记指数高于PA和非侵袭性CXPA的恶性成分（M-非侵袭性CXPA; P <0.01）。与PA相比，在M-非侵袭性CXPA和WI CXPA中观察到细胞周期蛋白E阳性染色增加（P = 0.006）。与PA相比，M-非侵袭性CXPA和WI CXPA中p63表达水平显著降低（P = 0.007）。Ki-67、cyclin E和p63表达的增加或减少可能提示PA和CXPA的增殖差异。(Oral外科口腔医学口腔病理学口腔放射学2012;113：667-672）
Objective. A set of cell proliferation-related molecular markers was used to detect the differences in proliferative activity between benign pleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma (CXPA).Study Design. Seventy samples comprising 53 PAs, 10 noninvasive and 7 widely invasive (WI) CXPAs were selected. Immunohistochemical staining was used to detect Ki-67, cyclin E, and p63 expression.Results. The average Ki-67 labeling index of WI CXPAs was higher than that of PAs and the malignant component of noninvasive CXPAs (M-noninvasive CXPA; P < .01). An increased cyclin E-positive staning was observed in M-noninvasive CXPAs and WI CXPAs compared with PAs (P = .006). The p63 expression levels were notably decreased in M-noninvasive CXPAs and WI CXPAs compared with PAs (P = .007).Conclusions. The data support that increased or decreased expression of Ki-67, cyclin E, and p63 may indicate the proliferative differences between PA and CXPA. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;113:667-672)