Meiosis in Plasmodium: how does it work?
Meiosis in Plasmodium: how does it work?
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DOI：
10.1016/j.pt.2023.07.002
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发表时间：
2023-09-13
影响因子：
9.6
通讯作者：
Tewari，Rita
中科院分区：
文献类型：
--
作者：
Guttery，David S.;Zeeshan，Mohammad;Tewari，Rita
减数分裂是有性细胞分裂，是真核生物产生单倍体配子的过程。与典型的真核生物模型相比，顶复门寄生虫的减数分裂似乎偏离了所涉及的分子机制;疟原虫减数分裂的生物学及其通过翻译后修饰的调控在很大程度上尚未探索。在这里，我们讨论了细胞生物学，进化生物信息学和全基因组功能研究的技术进步对我们理解顶复门减数分裂的影响。这些寄生虫包括恶性疟原虫、刚地弓形虫和艾美耳球虫，对人类和动物健康有重大的社会经济影响。了解寄生虫生命周期中的这一关键阶段可能会很好地揭示治疗干预的有吸引力的目标。
Meiosis is sexual cell division, a process in eukaryotes whereby haploid gametes are produced. Compared to canonical model eukaryotes, meiosis in apicomplexan parasites appears to diverge from the process with respect to the molecular mechanisms involved; the biology ofPlasmodiummeiosis, and its regulation by means of post-translational modification, are largely unexplored. Here, we discuss the impact of technological advances in cell biology, evolutionary bioinformatics, and genome-wide functional studies on our understanding of meiosis in the Apicomplexa. These parasites, includingPlasmodium falciparum, Toxoplasma gondii, andEimeriaspp.,have significant socioeconomic impact on human and animal health. Understanding this key stage during the parasite's life cycle may well reveal attractive targets for therapeutic intervention.