Atrial fibrillation is associated with hematopoietic tissue activation and arterial inflammation.
Atrial fibrillation is associated with hematopoietic tissue activation and arterial inflammation.
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DOI：
10.1007/s10554-015-0766-z
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Tawakol A
中科院分区：
文献类型：
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作者：
Joseph P;Ishai A;MacNabb M;Abdelbaky A;Lavender ZR;Ruskin J;Nahrendorf M;Tawakol A
炎症与心房颤动（AF）的发生有关。产生炎症白细胞的造血组织的活性与全身炎症、动脉炎症和心血管事件密切相关，但其与房颤的关系尚不清楚。使用 18F-氟脱氧葡萄糖 (FDG) 正电子发射断层扫描 (PET) 成像，我们检查了 AF 是否与脾代谢活动和血管炎症相关。我们对 70 名参与者进行了一项横断面研究：其中 35 名患有 AF，他们（按年龄、性别和活动性癌症病史）与 35 名没有 AF 的对照组相匹配。通过 PET 平均 FDG 最大标准摄取值 (SUV Max) 测量脾代谢活动和血管主动脉炎症。我们检查了 1) AF 与脾脏活动之间的关系，以及 2) AF 与主动脉炎症之间的关系。人群的平均年龄为 68.13 (SD 8.98) 岁，46 名 (65%) 参与者为男性。 AF 参与者的脾脏活动较高（2.31 (SD 0.45) vs. 2.07 (0.37)，p = 0.024），并且在调整人口统计和临床协变量后仍然显着。 AF 参与者的主动脉炎症也较高（2.22 (SD 0.44) vs. 1.91 (SD 0.44)，p = 0.004），并且在多变量分析中仍然显着。主动脉炎症和脾脏活动高度相关（Pearson R = 0.61，p<0.001）心房颤动与较高的造血组织活化和动脉炎症相关。需要进一步的研究来阐明心脾轴与房颤相关的机制。
Inflammation is associated with the development of atrial fibrillation (AF). Activity in hematopoietic tissues, which produce inflammatory leukocytes, is closely related to systemic inflammation, arterial inflammation and cardiovascular events, but its relationship to AF is unknown. Using 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging, we examined whether AF associates with splenic metabolic activity and vascular inflammation. We conducted a cross sectional study of 70 participants: 35 with AF, who were matched (by age, sex and history of active cancer) to 35 controls without AF. Splenic metabolic activity and vascular aortic inflammation were measured by the mean FDG maximum standard uptake values (SUV Max) by PET. We examined 1) the relationship between AF and splenic activity, and 2) AF and aortic inflammation. The mean age of the population was 68.13 (SD 8.98) years and 46 (65%) participants were male. Splenic activity was higher in AF participants (2.31 (SD 0.45) vs. 2.07 (0.37), p = 0.024), and remained significant after adjusting for demographic and clinical covariates. Aortic inflammation was also higher in AF participants (2.22 (SD 0.44) vs. 1.91 (SD 0.44), p = 0.004), and remained significant on multivariable analysis. Aortic inflammation and splenic activity were highly correlated (Pearson R = 0.61, p<0.001) Atrial fibrillation is associated with higher hematopoietic tissue activation and arterial inflammation. Further studies are needed to clarify the mechanisms by which this cardio-splenic axis is implicated in AF.