Fetal exposure to maternal cortisol
Fetal exposure to maternal cortisol
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DOI：
10.1016/s0140-6736(05)60824-0
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发表时间：
1998-08-29
期刊：
影响因子：
168.9
通讯作者：
Glover, V
中科院分区：
文献类型：
--
作者：
Gitau, R;Cameron, A;Glover, V
母体和胎儿皮质醇之间的关系一直存在争议。Schwartz 1认为，母体皮质醇对胎儿皮质醇浓度的影响很大，直到分娩的关键事件。与此相反，Benediktsson和Seckl 2指出，胎盘11β-羟基类固醇脱氢酶的高活性在妊娠早期和中期将母体皮质醇从胎儿中排除，并且皮质醇在任何阶段都不容易穿过人类胎盘。然而，引用的研究没有比较配对的母体和胎儿浓度。先前对母体皮质醇和胎儿皮质醇配对样本的研究表明，没有显着的相关性，但浓度范围很窄。我们测量了在妊娠13-35周（n= 43）时从临床指征胎儿测试中采集的成对母体和胎儿静脉血样中的血浆皮质醇浓度。所有妇女都签署了机构伦理委员会要求的知情同意书。我们排除了
The relation between maternal and fetal cortisol has been disputed. Schwartz1 suggests that maternal cortisol contributes much to fetal cortisol concentration until the key events of parturition. By contrast, Benediktsson and Seckl2 state that high placental 11β-hydroxysteroid-dehydrogenase activity excludes maternal cortisol from the fetus in early and mid gestation, and that cortisol does not cross the human placenta readily at any stage. The studies cited do not, however, compare paired maternal and fetal concentrations. Previous studies of paired maternal-cortisol and fetal-cortisol samples have shown no significant correlation, but had narrow ranges of concentrations. We measured plasma cortisol concentrations in paired maternal and fetal venous samples from blood taken for clinically-indicated fetal testing at 13–35 weeks’ gestation (n= 43). All women signed informed consent, required by the institutional ethics committee. We excluded fetuses that