A longitudinal study of cannabis use increasing the use of asthma medication in young Norwegian adults
A longitudinal study of cannabis use increasing the use of asthma medication in young Norwegian adults
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DOI：
10.1186/s12890-019-0814-x
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发表时间：
2019-02-26
影响因子：
3.1
通讯作者：
von Soest, Tilmann
中科院分区：
文献类型：
--
作者：
Bramness, Jorgen G.;von Soest, Tilmann
少数研究表明，使用大麻会增加支气管哮喘的风险。然而，缺乏能够控制已知支气管哮喘危险因素的纵向研究。方法：基于人群的纵向研究数据包括2602名年轻成年人，随访13年，结合挪威国家处方数据库中哮喘药物（(2)-肾上腺素能受体激动剂和吸入糖皮质激素）的个人处方数据，涵盖整个挪威人口。测量了当前大麻使用情况、性别、年龄、受教育年限、体重指数（BMI; kg/m(2)）和当前吸烟情况。结果哮喘药物处方与女性性别、自述早期哮喘和过敏、每日吸烟和目前使用大麻有关。在一个调整了性别、年龄、受教育年限、身体质量指数、早期自我报告的哮喘和过敏以及目前吸烟情况的模型中，目前吸食大麻的人服用哮喘药物处方的优势比为1.71 （95% CI: 1.06-2.77; p=0.028）。这表明，即使考虑到已知的危险因素，大麻也是支气管哮喘或使用哮喘药物的危险因素。高危人群应避免通过吸烟摄入大麻。
BackgroundA small number of studies have shown that the use of cannabis increases the risk of bronchial asthma. There is, however, a paucity of longitudinal studies which are able to control for known risk factors of bronchial asthma.MethodsSurvey data from a population-based longitudinal study encompassing 2602 young adults followed for 13years were coupled with individual prescription data on asthma medication ((2)-adrenergic receptor agonists and glucocorticoids for inhalation) from the Norwegian national prescription database, which covers the entire Norwegian population. Current cannabis use, gender, age, years of education, body mass index (BMI; kg/m(2)) and current smoking were measured.ResultsPrescription of asthma medication was associated with female gender, self-reported earlier asthma and allergies, daily tobacco smoking and current cannabis use. In a model adjusting for gender, age, years of education, BMI, earlier self-reported asthma and allergies and current tobacco smoking the odds ratio for a current cannabis user to fill prescriptions for asthma medication was 1.71 (95% CI: 1.06-2.77; p=0.028).ConclusionsThis suggests that cannabis is a risk factor for bronchial asthma or use of asthma medication even when known risk factors are taken into consideration. Intake of cannabis through smoking should be avoided in persons at risk.