Recoverin-associated retinopathy: A clinically and immunologically distinctive disease
Recoverin-associated retinopathy: A clinically and immunologically distinctive disease
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DOI：
10.1016/s0002-9394(98)00149-4
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发表时间：
1998-08-01
影响因子：
4.2
通讯作者：
Gery, I
中科院分区：
文献类型：
--
作者：
Whitcup, SM;Vistica, BP;Gery, I
目的：比较患有类似癌症相关视网膜病的临床状况的患者对视网膜抗原的免疫反应与患有其他视网膜变性或葡萄膜炎的患者的免疫反应。方法：在一名患有类似癌症相关视网膜病的疾病的患者、三名患有其他视网膜变性的患者和八名患有葡萄膜炎的患者中测定了对视网膜S抗原和恢复素的细胞和体液免疫反应。 结果：细胞免疫反应仅在患有类似癌症相关视网膜病变的患者中发现了针对恢复素的作用。该患者和三名视网膜变性患者之一的抗恢复素抗体水平升高，但八名葡萄膜炎患者均未发现该抗体水平升高。相比之下，在大多数研究的患者中发现了对视网膜S抗原的中等淋巴细胞反应，并且这种反应在患者组之间没有区别。所有测试患者的视网膜 S 抗原血清抗体水平也相似。来自患有类似癌症相关视网膜病的疾病的患者的血清对视杆细胞、视锥细胞、外丛状层和一些视锥双极细胞产生了强烈的免疫染色，但来自葡萄膜炎或其他视网膜变性患者的血清没有显示出与视网膜的特异性反应性。结论：我们建议将这种免疫学和临床上独特的情况称为恢复相关视网膜病，并且我们认为针对恢复的细胞免疫反应可能是一个显着的区别。该疾病的特征。 （美国眼科杂志 1998 年；126：230-237。(C) 1998 年，Elsevier Science Inc. 保留所有权利。）。
PURPOSE: To compare the immune response to retinal antigens in a patient with a clinical condition resembling cancer-associated retinopathy with the immune responses of patients with other retinal degenerations or uveitis.METHODS: Cellular and humoral immune responses to retinal S-antigen and recoverin were determined in one patient with disease resembling cancer-associated retinopathy, three patients with other retinal degenerations, and eight patients with uveitis.RESULTS: A cellular immune response against recoverin was found only in the patient with the condition resembling cancer-associated retinopathy. Elevated levels of antibody against recoverin were found in this patient and in one of the three patients with a retinal degeneration, but in none of the eight patients with uveitis. In contrast, moderate lymphocyte responses to retinal S-antigen were found in most of the patients studied, and this response did not distinguish among the patient groups. Levels of serum antibodies against retinal S-antigen were also similar in all patients tested. Serum from the patient with disease resembling cancer-associated retinopathy produced strong immunostaining of the rods, cones, outer plexiform layer, and some cone bipolar cells, but serum from the patients with uveitis or other retinal degenerations did not show specific reactivity with the retina.CONCLUSIONS: We propose that this immunologically and clinically distinctive condition be termed recoverin-associated retinopathy, and we suggest that a cellular immune response against recoverin may be a distinguishing feature of the disorder. (Am J Ophthalmol 1998;126:230-237. (C) 1998 by Elsevier Science Inc. Al rights reserved.).