Comparison of auditory, somatosensory, and visually instructed and internally generated finger movements: a PET study.
Comparison of auditory, somatosensory, and visually instructed and internally generated finger movements: a PET study.
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听觉、体感、视觉指导和内部产生的手指运动的比较：一项 PET 研究。
DOI：
10.1006/nimg.2001.0780
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发表时间：
2001
期刊：
影响因子：
5.7
通讯作者：
Hallett,M
中科院分区：
文献类型：
--
作者：
Weeks,RA;Honda,M;Catalan,MJ;Hallett,M
我们试图确定如何模式的大脑激活，特别是在额叶运动区，在执行条件运动任务是依赖于形式的指令（视觉，听觉，或体感）。区域脑血流量（rCBF）的变化与外部指示的运动也进行了比较，内部产生的，自我起搏，运动。我们使用正电子发射断层扫描（PET）与示踪剂H215O测量22名健康志愿者的rCBF。外部刺激包括随机呈现的单或双脉冲使用一个单一的方式为每个条件。在运动扫描中，受试者使用右手的食指和中指分别按下左按钮和右按钮，分别进行单脉冲和双脉冲。在控制扫描中，受试者被要求在没有运动反应的情况下秘密地区分单刺激和双刺激。使用常规减法技术分析数据，统计阈值Z > 2.33，多重比较校正。当三个外部指示的运动条件之间的激活差异进行了统计学比较，非显着的趋势增加的rCBF在感觉皮层的方式的线索，但没有差异活动在皮层运动区。与外部触发的运动相比，内部产生的运动与双侧内侧和外侧前运动区、背外侧前额叶和上级顶叶区域的增强激活相关，这在很大程度上证实了以前的报告。这些数据表明，在区域水平上，特定于模态的处理条件运动任务不发生在额叶运动区，可能是局限于感觉区。
We sought to determine how the pattern of cerebral activation, and in particular in frontal motor areas, during the performance of conditional motor tasks is dependent upon the modality of instruction (visual, auditory, or somatosensory). Regional cerebral blood flow (rCBF) changes with externally instructed movements were also compared with internally generated, self-paced, movements. We used positron emission tomography (PET) with the tracer H215O to measure rCBF in 22 healthy volunteers. External stimuli consisted of the randomized presentation of single or double impulses using a single modality for each condition. In the movement scans, the subjects used the index and middle fingers of their right hands to press a left button for a single and a right button for a double impulse, respectively. In the control scans, subjects were required to covertly distinguish a single from a double stimulus without a motor response. Data were analyzed using conventional subtraction techniques with a statistical threshold of Z > 2.33 with corrections for multiple comparisons. When the activation differences between the three externally instructed movement conditions were statistically compared, nonsignificant trends toward increased rCBF in the sensory cortex of the modality of the cue were observed but no differential activity in cortical motor areas. Internally generated movements, when compared to externally triggered movements, were associated with enhanced activation in bilateral medial and lateral premotor, dorsolateral prefrontal and superior parietal regions, largely confirming previous reports. The data indicate that, on a regional level, modality-specific processing in a conditional motor task does not occur in frontal motor areas and is probably confined to sensory areas.