Side-scattered finger-photoplethysmography: Experimental investigations towards practical noninvasive measurement of blood glucose
Side-scattered finger-photoplethysmography: Experimental investigations towards practical noninvasive measurement of blood glucose
复制标题
侧向散射手指光电体积描记法：实用无创血糖测量的实验研究
DOI：
10.1117/1.jbo.22.6.067001
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发表时间：
2017
影响因子：
3.5
通讯作者：
Yamakoshi K
中科院分区：
文献类型：
--
作者：
Yamakoshi Y;Matsumura K;Yamakoshi T;Lee J;Rolfe P;Kato Y;Shimizu K;Yamakoshi K
本研究的目的是发现一种简单/方便的辐射源和检测器的几何布置，以获取具有血糖（BGL）吸收波长区域的手指光电容积描记图（PPG），从而实现实用的无创BGL测量。首先，我们比较了具有三个波长的PPG：808 nm（无水吸收）、1160 nm（具有弱水吸收）和1600 nm（具有接近峰值BGL吸收和强水吸收），同时源-检测器间距围绕指尖周向连续增加。在10名健康受试者中，我们在任何入射位置观察到808和1160 nm处PPG信号的清晰心脏相关搏动分量，信噪比大于15 dB（），但只有当源-检测器距离小于指尖周围3 mm时，才可能在1600 nm处检测到可靠的PPG信号，信噪比大于10 dB。第二，利用这种布置，使用六个波长进行实验以覆盖葡萄糖吸收带（从1550至1749 nm），获得具有或多或少15 dB的脉动PPG信号。通过本实验，用于检测通过组织的前向散射辐射和侧向散射辐射的源和检测器的这种正交布置适合于具有BGL测量潜力的波长区域的PPG测量。
The aim of this study was to discover a simple/convenient geometrical arrangement of radiation sources and detector to acquire finger-photoplethysmograms (PPGs) with wavelength regions of blood glucose (BGL) absorption, toward practical noninvasive BGL measurement. First, we compared PPGs with three wavelengths: 808 nm (without water absorption), 1160 nm (with weak water absorption), and 1600 nm (with nearly peak BGL absorption and strong water absorption), while the source-detector spacing was successively increased circumferentially around a fingertip. In 10 healthy subjects, we observed clear cardiac-related pulsatile components of PPG signals at 808 and 1160 nm in any incident positions with more than 15 dB of signal-to-noise ratio (), but reliable PPG detections at 1600 nm with more than 10 dB ofwas only possible when the source-detector distance was less than 3 mm around the fingertip circumference. Second, with this arrangement, an experiment was performed using six wavelengths to cover glucose absorption bands (from 1550 to 1749 nm), obtaining pulsatile PPG signals with more or less 15 dB of. Through the present experiments, this orthogonal arrangement of the source and detector to detect forward- and side-scattered radiation through the tissue is appropriate for PPG measurements with wavelength regions where there is potential for BGL measurement.