Menopausal status should be taken into consideration for patients with luminal a breast cancer in terms of the effect of differential biology on prognosis.
Menopausal status should be taken into consideration for patients with luminal a breast cancer in terms of the effect of differential biology on prognosis.
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就鉴别生物学对预后的影响而言，管腔型乳腺癌患者应考虑绝经状态。
DOI：
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发表时间：
2013
影响因子：
45.3
通讯作者：
H. Iwase
中科院分区：
文献类型：
--
作者：
Yutaka Yamamoto;M. Yamamoto;H. Iwase
在高雌激素水平下产生的ER阳性癌症干细胞如何被认为与在低雌激素水平下产生的ER阳性癌症干细胞相同？此外，我们假设ER阳性肿瘤由三种类型组成--绝经前通过筛查发现的肿瘤；绝经前产生但在绝经后发现的肿瘤；以及绝经后既产生又检测到的肿瘤--这三种ER阳性亚型可能很难正确区分。从逻辑上讲，这些肿瘤在发育过程中会根据不同的情况具有不同的生物学特征。此外，Haynes等人最近报道，在ER阳性的乳腺癌中，PR的表达水平在不同的月经周期中显著不同。总之，在ER阳性的乳腺癌人群中，应该区分绝经前和绝经后的患者，并评估他们各自的预后。我们推测，在接受内分泌治疗的ER阳性肿瘤患者中，PR表达水平对预后的影响在绝经前和绝经后患者之间可能不同。如果作者能为我们提供他们新提出的基于免疫组织化学的根据绝经状态的管腔A分类的预后价值的信息，我们将不胜感激。
how can an ER-positive cancer stem cell produced under high levels of estrogen be considered the same as an ER-positive cancer stem cell produced under low levels of estrogen? Moreover, we hypothesize that ER-positive tumors consist of three types—tumors that were both generated and detected by screening before menopause; tumors gen- erated before menopause but detected after menopause; and tumors that were both generated and detected after menopause—and that it may be difficult to distinguish correctly between these three ER- positive subtypes. Logically, these tumors would be expected to have different biologic features according to the different circumstances during development. Furthermore, Haynes et al 5 recently reported that expression levels of PR significantly differed across the menstrual cycle in ER-positive breast cancer. In conclusion, premenopausal and postmenopausal patients among the ER-positive breast cancer population should be distin- guished and their respective prognoses evaluated. We speculate that the prognostic impact of PR expression levels among patients with ER-positive tumors treated with endocrine therapy may differ be- tween premenopausal and postmenopausal patients. We would be grateful if the authors would provide us with information on the prognostic value of their newly proposed immunohistochemistry- based luminal A classification according to menopausal status.
影响因子：
45.3
作者：
Prat, Aleix;Cheang, Maggie Chon U.;Perou, Charles M.
通讯作者：
Perou, Charles M.