Natural regulatory T cells control the development of atherosclerosis in mice
Natural regulatory T cells control the development of atherosclerosis in mice
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DOI：
10.1038/nm1343
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发表时间：
2006-02-01
期刊：
影响因子：
82.9
通讯作者：
Mallat, Z
中科院分区：
文献类型：
--
作者：
Ait-Oufella, H;Salomon, BL;Mallat, Z
动脉粥样硬化是一种免疫炎症性疾病，由动脉壁脂质积聚引起，并导致心肌梗死和中风（1，2）。在这里，我们发现，自然产生的CD4（+）CD25（+）调节性T细胞，积极维持自身和非自身抗原的免疫耐受性（3，4），是几种小鼠模型动脉粥样硬化的强大抑制剂。这些结果为动脉粥样硬化的免疫发病机制提供了新的见解，并可能导致新的治疗方法，包括使用调节性T细胞进行免疫调节。
Atherosclerosis is an immunoinflammatory disease elicited by accumulation of lipids in the artery wall and leads to myocardial infarction and stroke(1,2). Here, we show that naturally arising CD4(+)CD25(+) regulatory T cells, which actively maintain immunological tolerance to self and nonself antigens(3,4), are powerful inhibitors of atherosclerosis in several mouse models. These results provide new insights into the immunopathogenesis of atherosclerosis and could lead to new therapeutic approaches that involve immune modulation using regulatory T cells.