Quantitative analysis of alprazolam in human plasma by combined capillary gas chromatography/negative ion chemical ionization mass spectrometry.
Quantitative analysis of alprazolam in human plasma by combined capillary gas chromatography/negative ion chemical ionization mass spectrometry.
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毛细管气相色谱/负离子化学电离质谱联用定量分析人血浆中的阿普唑仑。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
U. Liskevych
中科院分区：
文献类型：
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作者：
J. Javaid;U. Liskevych
本报告描述了一个高灵敏度的毛细管气相色谱/质谱法定量阿普唑仑在人血浆中的程序。在碱性pH值下，用苯异戊醇（98：2，v/v）从血浆中提取阿普唑仑，并直接进行分析，无需任何衍生化。三唑仑，也是一种三唑苯并二氮卓衍生物，被用作内标物，因为其提取特性与阿普唑仑相似。通过负离子化学电离和选择离子监测，阿普唑仑（m/z 308）和三唑仑（m/z 306）达到高灵敏度。在1.0-20 ng阿普唑仑/ml血浆浓度范围内，该方法的日内变异系数为5.5%。
This report describes a highly sensitive capillary gas chromatographic/mass spectrometric procedure for the quantification of alprazolam in human plasma. Alprazolam was extracted from plasma at basic pH with benzeneisoamyl alcohol (98:2, v/v) and analysed directly without any derivatization. Triazolam, also a triazolobenzodiazepine derivative, was used as an internal standard because its extraction characteristics were similar to alprazolam. High sensitivity was achieved by negative ion chemical ionization and selected ion monitoring for alprazolam (m/z 308) and triazolam (m/z 306). The within-day coefficient of variation of the method over the concentration range 1.0-20 ng alprazolam per ml of plasma was 5.5%.
三唑并苯二氮卓类药物阿普唑仑和三唑仑的电子捕获气相色谱分析。
DOI：
10.1016/s0378-4347(00)80261-3
发表时间：
1981
期刊：
Journal of chromatography
影响因子：
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作者：
Greenblatt,DJ;Divoll,M;Moschitto,LJ;Shader,RI
通讯作者：
Shader,RI