Interactions between co-existing beta-adrenoceptor subtypes in continuous cell lines.
Interactions between co-existing beta-adrenoceptor subtypes in continuous cell lines.
复制标题
连续细胞系中共存的β-肾上腺素受体亚型之间的相互作用。
DOI：
10.1042/bst0211109
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发表时间：
1993
影响因子：
3.9
通讯作者：
Zhong,H
中科院分区：
文献类型：
--
作者：
Minneman,KP;Esbenshade,TA;Zhong,H
现在已经确定了各种神经递质和激素的受体亚型的大家族。对于乙酰胆碱、去甲肾上腺素、谷氨酸、γ-氨基丁酸和5-羟色胺等重要的神经递质，似乎有10种或更多种不同的受体亚型。由单一神经递质激活的如此多的受体亚型持续存在的进化压力尚不清楚。然而，现在看来，一种神经递质的多种受体亚型可能共存于一个细胞上，对特定神经递质的反应通常由多种共存亚型的组合介导。这种情况将对细胞信号传导的生物学以及基于受体特异性激动剂和拮抗剂的合理疗法的开发具有重要意义。然而，对于同一细胞上共存的单一神经递质的多种亚型的作用和相互作用知之甚少。
Large families of receptor subtypes have now been identified for a variety of neurotransmitters and hormones. There appear to be ten or more pharmacologically distinct receptor subtypes for such important neurotransmitters as acetylcholine, noradrenaline, glutamate, y-aminobutyric acid and serotonin. The evolutionary pressure for the continued existence of so many receptor subtypes that are activated by a single neurotransmitter is not yet clear. However, it seems likely now that multiple receptor subtypes for a single neurotransmitter coexist on a single cell, and that responses to a particular neurotransmitter will often be mediated by combinations of multiple co-existing subtypes. Such a situation would have important implications for the biology of cell signalling, as well as for the development of rational therapeutics based on receptor-specific agonists and antagonists. However, little is known yet about the actions and interactions of multiple subtypes for a single neurotransmitter that co-exist on the same cell.