Antischistosome IgG4 and IgE responses are affected differentially by chemotherapy in children versus adults
Antischistosome IgG4 and IgE responses are affected differentially by chemotherapy in children versus adults
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DOI：
10.1093/infdis/173.5.1242
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发表时间：
1996-05-01
影响因子：
6.4
通讯作者：
Yazdanbakhsh, M
中科院分区：
文献类型：
--
作者：
Grogan, JL;Kremsner, PG;Yazdanbakhsh, M
对110例血吸虫感染者化疗前和化疗后5周的特异性IgG_4、IgE反应及多克隆细胞因子谱进行了研究。产蛋量和循环阳极抗原的显著下降与对SEA的IgG 4应答的显著下降有关化疗后，儿童抗成虫抗原IgG 4、IgE和抗SEA IgE均升高，而成人无变化。这表明，免疫调节机制在S。血吸虫感染的成人与感染的儿童不同。在用抗CD 3抗体刺激全血后测定治疗对细胞因子谱的影响。治疗后白细胞介素-4产生的显著减少表明蠕虫负荷的减少可能导致Th 2型细胞数量的减少。
Specific IgG4 and IgE responses and polyclonal cytokine profiles were studied in 110 Schistosoma haematobium-infected persons before and 5 weeks after chemotherapy, Pretreatment IgG4 responses to soluble egg antigen (SEA) correlated with intensity of infection, After chemotherapy, a significant decrease in egg output and circulating anodic antigen was associated with a substantial drop in the IgG4 response to SEA (IgG4-SEA) in adults and in children, suggesting that egg laying is a major stimulus for IgG4-SEA, After chemotherapy, IgG4 and IgE to adult worm antigen and IgE to SEA increased in children but remained unchanged in adults. This indicates that the immunoregulatory mechanisms operative in S. haematobium-infected adults differ from those in infected children, The effect of treatment on cytokine profiles was determined following stimulation of whole blood with anti-CD3 antibodies, A significant decrease in interleukin-4 production after treatment indicated that reduction in helminth load may lead to a reduced number of Th2-type cells.