Dynamic optimization of odor representations by slow temporal patterning of mitral cell activity
Dynamic optimization of odor representations by slow temporal patterning of mitral cell activity
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DOI：
10.1126/science.291.5505.889
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发表时间：
2001-02-02
期刊：
影响因子：
56.9
通讯作者：
Laurent, G
中科院分区：
文献类型：
--
作者：
Friedrich, RW;Laurent, G
嗅球（OB）中的二尖瓣细胞（MC）以缓慢的时间放电模式对气味作出反应。因此，在整个刺激过程中，每种气味通过MC群体的活动模式的表示以气味特异性的方式连续变化。在斑马鱼OB中，我们发现这种分布式时间模式逐渐降低了相关气味的整体表示之间的相似性，从而使每种气味的表示随着时间的推移变得更加具体。在这个过程中，单个MC的调谐并没有变得尖锐。因此，个别的响应MC没有变得更具体，但气味编码MC组件改变，使其重叠减少。这种优化的集成表示没有发生在嗅觉传入，但OB电路动态。因此，时间可以逐渐优化感觉网络中的刺激表征。
Mitral cells (MCs) in the olfactory bulb (OB) respond to odors with slow temporal firing patterns. The representation of each odor by activity patterns across the MC population thus changes continuously throughout a stimulus, in an odor-specific manner. In the zebrafish OB, we found that this distributed temporal patterning progressively reduced the similarity between ensemble representations of related odors, thereby making each odor's representation more specific over time. The tuning of individual MCs was not sharpened during this process. Hence, the individual responses of MCs did not become more specific, but the odor-coding MC assemblies changed such that their overlap decreased. This optimization of ensemble representations did not occur among olfactory afferents but resulted from OB circuit dynamics. Time can therefore gradually optimize stimulus representations in a sensory network.