The numerical matching of source and target populations in the CNS: The inferior olive to Purkinje cell projection
The numerical matching of source and target populations in the CNS: The inferior olive to Purkinje cell projection
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DOI：
10.1016/0165-3806(96)00069-7
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发表时间：
1996-10-23
期刊：
影响因子：
--
通讯作者：
Mariani, J
中科院分区：
文献类型：
--
作者：
Herrup, K;ShojaeianZanjani, H;Mariani, J
在发育的一个定义的关键时期：如果神经元群体的目标被移除，存活到成年期的神经元数量会大量减少，以前的研究发现源神经元数量是目标大小的严格线性函数，目前的工作将这些观察扩展到下橄榄->浦肯野细胞投射，使用了三种不同的模型系统：（i）lurcher野生型聚集嵌合体，（ii）staggerer野生型嵌合体和（iii）在不同近交系小鼠品系中发现的浦肯野细胞数中天然存在的多态性。对下橄榄核中的神经元总数进行计数，并绘制为对侧小脑皮质、In lurcher突变体和嵌合体中浦肯野细胞数量的函数。这些值之间的关系用直线很好地描述。这表明，像颗粒->浦肯野细胞回路一样，橄榄->浦肯野细胞回路使用线性算法来实现数字平衡。另外两个模型系统的结果并不那么明确。在交错嵌合体中，我们发现神经元和靶细胞数量之间只有粗略的相关性，而在近交a系中，根本没有明显的相关性。这些发现表明，归根结底，有多种因素参与了橄榄细胞存活到成年期的数量的决定。维持侧支和传入输入的潜在贡献进行了讨论，以及可能存在不同的子电路的橄榄小脑连接，每个都有自己的数值匹配功能。
During a defined critical period of development: if the target of a neuronal population is removed, there is a massive decrease in the number of neurons that survive into adulthood, Previous studies have found that source neuron number is a strictly linear function of target size, The current work extends these observations to the inferior olive --> Purkinje cell projection, Three distinct model systems have been used: (i) lurcher wild-type aggregation chimeras, (ii) staggerer wild-type chimeras and (iii) naturally occurring polymorphisms in Purkinje cell number found in different Inbred mouse strains. Total neuron numbers were counted in the inferior olive and plotted as a function of the number of Purkinje cells in the contralateral cerebellar cortex, In lurcher mutants and chimeras. the relationship between these values is well described by a straight line. This suggests that, like the granule --> Purkinje cell circuit, the olive --> Purkinje cell circuit uses a linear algorithm to achieve a numerical balance. The results from the two other model systems were not as clear cut. Ln the staggerer chimeras, we found only a rough correlation between neuron and target numbers and in the inbred a strains there was no discernible relationship at all. These findings indicate that in the final analysis, there are multiple factors involved in the determination of the number of olive cells surviving into adulthood. The potential contribution of sustaining collaterals and afferent inputs is discussed as well as the possible existence of different subcircuits of olivocerebellar connections, each with its own numerical matching function.