Tridecaptin-inspired antimicrobial peptides with activity against multidrug-resistant Gram-negative bacteria
Tridecaptin-inspired antimicrobial peptides with activity against multidrug-resistant Gram-negative bacteria
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DOI：
10.1039/c9md00031c
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发表时间：
2019-03-01
期刊：
影响因子：
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通讯作者：
Cochrane, Stephen A.
中科院分区：
文献类型：
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作者：
Ballantine, Ross D.;McCallion, Conor E.;Cochrane, Stephen A.
抗菌肽是潜在的抗生素候选物的丰富来源。tridecaptin是一个线性脂十三肽家族，易于合成并显示出对革兰氏阴性菌的强活性。然而，它们的组成包括几种昂贵的氨基酸，如d/l二氨基丁酸和d-别异亮氨酸，显著增加了它们的合成成本。在此，我们报道了一系列新的tridecaptin衍生物，其合成成本低得多，并且保留了对多重耐药革兰氏阴性菌的强活性。
Antimicrobial peptides are a rich source of potential antibiotic candidates. The tridecaptins, a family of linear lipo-tridecapeptides, are easily synthesized and show strong activity against Gram-negative bacteria. However, their composition includes several expensive amino acids, such as d/l diaminobutyric acid and d-allo-isoleucine, significantly increasing their cost of synthesis. Herein, we report a series of new tridecaptin derivatives that are much cheaper to synthesize and retain strong activity against multidrug-resistant Gram-negative bacteria.