A platinum-based fluorescent "turn on" sensor to decipher the reduction of platinum(iv) prodrugs
A platinum-based fluorescent "turn on" sensor to decipher the reduction of platinum(iv) prodrugs
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DOI：
10.1039/d2dt00124a
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发表时间：
2022-02-25
影响因子：
4
通讯作者：
Zhu, Guangyu
中科院分区：
文献类型：
--
作者：
Yao, Houzong;Zhu, Guangyu
我们报告了一种策略，使用荧光“打开”传感器，以量化减少铂（iv）前药在一个实时的模式，简单方便地监测荧光强度。具有高分子量的蛋白质，特别是那些在10和100 kDa之间的蛋白质，对细胞提取物中铂（IV）络合物的还原贡献更大。
We report a strategy to use a fluorescence "turn on" sensor to quantify the reduction of platinum(iv) prodrugs in a real-time mode by simply and conveniently monitoring the fluorescence intensity. Proteins with high molecular weights, especially those between 10 and 100 kDa, contribute more to the reduction of the platinum(iv) complex in cell extracts.