Relationship of obesity with osteoporosis
Relationship of obesity with osteoporosis
复制标题
DOI：
10.1210/jc.2006-0572
复制
发表时间：
2007-05-01
影响因子：
5.8
通讯作者：
Deng, Hong-Wen
中科院分区：
文献类型：
--
作者：
Zhao, Lan-Juan;Liu, Yong-Jun;Deng, Hong-Wen
背景：肥胖与骨质疏松症的关系已被广泛研究，流行病学证据表明肥胖与骨量增加相关。目的：本研究的目的是通过考虑体重机械负荷对骨量的影响来重新评估肥胖与骨质疏松症之间的关系。方法：我们测量了两个不同种族的大样本的全身脂肪质量、瘦质量、脂肪百分比、体重指数和骨量：1988名无关的中国人和4489名白人。我们首先评估了不同表型之间的皮尔逊相关性。然后，我们解剖了未调整或调整体重的表型骨量。结果：在中国人和高加索人中，当调整体重对骨量的机械负荷效应时，脂肪质量(或脂肪质量百分比)与骨量之间的表型相关(包括其遗传和环境成分)呈负相关。在控制了总体重的机械负荷效应后，对按体重分层的受试者进行了进一步的多因素分析，证实了骨量和脂肪量之间的负相关关系。结论：增加脂肪质量可能对骨量没有好处。
Context: The relationship between obesity and osteoporosis has been widely studied, and epidemiological evidence shows that obesity is correlated with increased bone mass. Previous analyses, however, did not control for the mechanical loading effects of total body weight on bone mass and may have generated a confounded or even biased relationship between obesity and osteoporosis.Objective: The objective of this study was to reevaluate the relationship between obesity and osteoporosis by accounting for the mechanical loading effects of total body weight on bone mass.Methods: We measured whole body fat mass, lean mass, percentage fat mass, body mass index, and bone mass in two large samples of different ethnicity: 1988 unrelated Chinese subjects and 4489 Caucasian subjects from 512 pedigrees. We first evaluated the Pearson correlations among different phenotypes. We then dissected the phenotypic bone mass unadjusted or adjusted for body weight. This allowed us to compare the results with and without controlling for mechanical loading effects of body weight on bone mass.Results: In both Chinese and Caucasian subjects, when the mechanical loading effect of body weight on bone mass was adjusted for, the phenotypic correlation (including its genetic and environmental components) between fat mass (or percentage fat mass) and bone mass was negative. Further multivariate analyses in subjects stratified by body weight confirmed the inverse relationship between bone mass and fat mass, after mechanical loading effects due to total body weight were controlled.Conclusions: Increasing fat mass may not have a beneficial effect on bone mass.