Glucose phosphorylation as a barrier to muscle glucose uptake
Glucose phosphorylation as a barrier to muscle glucose uptake
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DOI：
10.1111/j.1440-1681.2005.04190.x
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发表时间：
2005-04-01
影响因子：
2.9
通讯作者：
Fueger, PT
中科院分区：
文献类型：
--
作者：
Fueger, PT
1. 葡萄糖磷酸化是肌肉葡萄糖摄取途径的第一个不可逆步骤，由己糖激酶同工酶催化。2．虽然葡萄糖转运是基础条件下肌肉葡萄糖摄取的主要障碍，但葡萄糖磷酸化在高胰岛素血症或运动等刺激条件下成为肌肉葡萄糖摄取的重要障碍。3。高脂肪喂养会显着损害胰岛素和运动刺激的肌肉葡萄糖摄取。由于己糖激酶 II 过度表达可以纠正运动期间饮食引起的缺陷，因此葡萄糖磷酸化是高脂肪喂养后受损的一个部位。4。运动是诊断葡萄糖磷酸化缺陷的重要工具。
1. Glucose phosphorylation is the first irreversible step of the muscle glucose uptake pathway and is catalysed by a hexokinase isozyme.2. While glucose transport is the primary barrier to muscle glucose uptake during basal conditions, glucose phosphorylation becomes an important barrier to muscle glucose uptake during stimulated conditions such as hyperinsulinaemia or exercise.3. High fat feeding markedly impairs insulin- and exercise-stimulated muscle glucose uptake. As hexokinase II overexpression corrects this dietary-induced deficit during exercise, glucose phosphorylation is a site of impairment following high fat feeding.4. Exercise is an important tool for diagnosing deficits in glucose phosphorylation.