Metabolic pathways promoting cancer cell survival and growth.
Metabolic pathways promoting cancer cell survival and growth.
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DOI：
10.1038/ncb3124
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发表时间：
2015-04
影响因子：
21.3
通讯作者：
DeBerardinis RJ
中科院分区：
文献类型：
--
作者：
Boroughs LK;DeBerardinis RJ
癌基因的激活和肿瘤抑制因子的丢失促进癌症中的代谢重编程，导致营养摄取增强，以提供能量和生物合成途径。然而，实体瘤内的营养限制可能要求恶性细胞表现出代谢灵活性以维持生长和存活。在这里，我们强调这些自适应机制，并讨论了新出现的方法来探测体内肿瘤代谢和它们的潜力，以扩大恶性细胞的代谢库，甚至进一步。
Activation of oncogenes and loss of tumour suppressors promote metabolic reprogramming in cancer, resulting in enhanced nutrient uptake to supply energetic and biosynthetic pathways. However, nutrient limitations within solid tumours may require that malignant cells exhibit metabolic flexibility to sustain growth and survival. Here, we highlight these adaptive mechanisms and also discuss emerging approaches to probe tumour metabolism in vivo and their potential to expand the metabolic repertoire of malignant cells even further.