Plasma metabolomic profiles associated with infant food allergy with further consideration of other early life factors
Plasma metabolomic profiles associated with infant food allergy with further consideration of other early life factors
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DOI：
10.1016/j.plefa.2020.102099
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发表时间：
2020-08-01
影响因子：
3
通讯作者：
Sly, Peter
中科院分区：
文献类型：
--
作者：
Ellul, Susan;Marx, Wolfgang;Sly, Peter
背景：脂肪酸与生命早期的免疫发育有关。食物过敏提供了早期过敏性疾病的明确表型。鱼油和维生素 D 具有免疫调节特性。我们的目的是确定过去研究中 (i) 婴儿食物过敏和 (ii) 与食物过敏相关的因素的代谢组学特征，例如补充鱼油和生命早期血清 25OHD3 水平。 方法：使用 NMR 来量化 Barwon 婴儿研究 (n = 485) 中 1 岁婴儿血浆中的 73 种代谢物。使用逻辑回归模型来检查婴儿代谢组与婴儿食物过敏之间的关联。使用线性回归模型来描述母体鱼油补充和 25OHD3 水平与婴儿代谢物之间的关联。结果：较高的亚油酸：总脂肪酸 (FA) 比率和苯丙氨酸水平与较高的食物过敏几率相关。产前补充鱼油与二十二碳六烯酸 (DHA) 和 omega-3 相关代谢物水平呈正相关。出生后 1 岁时的 25OHD3 水平与多种 FA 测量值和肌酐呈正相关，与饱和 FA：总 FA 比率呈负相关。经过多重比较调整后，只有出生后 25OHD3 模式仍然存在。结论：食物过敏的婴儿在一岁时脂肪酸谱发生了改变。怀孕期间补充鱼油与 1 岁时较高的 DHA 和 omega-3 相关代谢物有关。关联性不大，最显着改变的代谢组学特征与出生后 25OHD3 水平有关。
Background: Fatty acids have been implicated in early life immune development. Food allergy provides a clear phenotype of early allergic disease. Fish oil and vitamin D have immune-modulating properties. We aimed to identify the metabolomic profile of (i) infant food allergy and (ii) factors linked to food allergy in past studies such as fish oil supplementation and serum 25OHD3 levels in early life.Methods: NMR was used to quantify 73 metabolites in plasma of 1 year old infants from the Barwon Infant Study (n = 485). Logistic regression models were used to examine associations between infant metabolome and food allergy in infants. Linear regression models were used to describe associations between maternal fish oil supplementation and 25OHD3 levels with infant metabolites.Results: A higher linoleic acid: total fatty acid (FA) ratio and phenylalanine level were associated with higher odds of food allergy. Antenatal fish oil supplementation was positively associated with docosahexaenoic acid (DHA) and omega-3 related metabolite levels. Postnatal 25OHD3 levels at 1 year of age were positively associated with several FA measures and creatinine and inversely with the saturated FA: total FA ratio. Only the postnatal 25OHD3 patterns persisted after adjustment for multiple comparisons.Conclusions: Infants with food allergy had altered fatty acid profiles at one year. Fish oil supplementation in pregnancy was associated with higher DHA and omega-3 related metabolites at 1 year of age. Associations were modest and the most robustly altered metabolomic profiles were with postnatal 25OHD3 levels.