Mental, Motor, and Language Development of Toddlers with Neurofibromatosis Type 1
Mental, Motor, and Language Development of Toddlers with Neurofibromatosis Type 1
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DOI：
10.1016/j.jpeds.2010.10.001
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发表时间：
2011-04-01
影响因子：
5.1
通讯作者：
North, Kathryn
中科院分区：
文献类型：
--
作者：
Lorenzo, Jennifer;Barton, Belinda;North, Kathryn
目的探讨1型神经纤维瘤病（NF 1）患儿的智力、运动和语言发育情况。研究设计采用Bayley婴儿发育量表（第二版）对39名NF 1患儿（年龄21-30个月）和42名年龄匹配的对照组儿童进行横断面研究。采用韦氏学龄前和小学智力量表（第三版）中的语言分测验评估基本词汇量。父母完成了问卷调查，评估孩子的表达语言，行为和执行功能。采用卡方检验、独立样本t检验、Mann-Whitney U检验和协方差分析等统计学方法对两组儿童的智力和运动发育进行比较。父母的反应表明，大多数的儿童与NF 1有延迟的语言技能。两组儿童之间的行为和执行功能没有显着差异。结论NF 1的儿童年龄为30个月，表现出早期的迹象，精神，运动和语言困难。2岁可能是进行初步发育评估的适当时间，以确定NF 1儿童的智力，运动和语言障碍。（J Pediatr 2011; 158：660-5）。
Objective To examine the mental, motor, and language development of toddlers with neurofibromatosis type 1 (NF1).Study design In this cross-sectional study, 39 toddlers with NF1 (aged 21-30 months) and 42 age-matched control children were assessed using the Bayley Scales of Infant Development, Second Edition. Basic vocabulary was assessed with the language subtests from the Wechsler Preschool and Primary Scale of Intelligence, Third Edition. Parents completed questionnaires evaluating the children's expressive language, behavior, and executive functioning. The chi(2) test, independent t test, Mann-Whitney U test, and analysis of covariance were used to examine differences between the two groups.Results The toddlers with NF1 had significantly poorer mental and motor development than the control participants. Parental responses indicated that most of the children with NF1 had delayed language skills. No differences in behavior and executive functioning were noted between the two groups of children.Conclusions Children with NF1 as young as age 30 months demonstrate early signs of mental, motor, and language difficulties. Age 2 years may be the appropriate time to performan initial developmental assessment to identify mental, motor, and language impairments in children with NF1. (J Pediatr 2011; 158:660-5).