Systemic inflammation markers in patients with aggressive periodontitis: a pilot study.
Systemic inflammation markers in patients with aggressive periodontitis: a pilot study.
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DOI：
10.1902/jop.2008.080192
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发表时间：
2008-12
影响因子：
4.3
通讯作者：
D. Shi;H. Meng;L. Xu;Li Zhang;Zhi-bin Chen;Xiang-hui Feng;R. Lu;Xiaojun Sun;X. Ren
中科院分区：
文献类型：
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作者：
D. Shi;H. Meng;L. Xu;Li Zhang;Zhi-bin Chen;Xiang-hui Feng;R. Lu;Xiaojun Sun;X. Ren
背景 牙周炎与全身健康之间的关联是显而易见的。然而，直到最近，还缺乏科学证据来定义侵袭性牙周炎 (AgP) 与全身性疾病之间的关系。本研究旨在探讨AgP患者外周血细胞和血清蛋白参数的特点。方法 招募 AgP 患者 (n = 150) 和健康对照 (n = 94)。检查了临床参数，包括探诊深度（PD）、临床附着水平（CAL）和严重部位的百分比。分析了血细胞变量，包括白细胞、中性粒细胞和淋巴细胞计数，以及血清蛋白参数，包括总蛋白、白蛋白、球蛋白和白蛋白/球蛋白比率。结果 与对照组相比，AgP 患者中性粒细胞数量和血清球蛋白水平升高（分别为 4.22 +/- 1.81 x 10(9)/l 与 3.20 +/- 0.91 x 10(9)/l 和 29.20 +/- 3.75 g/l 与 27.17 +/- 3.32 g/l；P <0.01）。 AgP 组的白蛋白水平和白蛋白/球蛋白比值低于对照组（分别为 47.65 +/- 2.45 g/l 与 48.88 +/- 2.13 g/l 和 1.66 +/- 0.24 与 1.83 +/- 0.24；P <0.01）。 AgP组中性粒细胞计数和血清球蛋白水平与PD、CAL平均值和严重部位百分比等临床参数呈正相关（P <0.05）；白蛋白水平和白蛋白/球蛋白比值与上述临床参数呈负相关（P <0.05）。结论 与对照组相比，AgP 患者的外周血白细胞数量和血清球蛋白水平可能升高，而血清白蛋白水平和白蛋白/球蛋白比率降低。这些变化可能与牙周破坏的严重程度有关。
BACKGROUND The association between periodontitis and systemic health is evident; however, until recently, there was a lack of scientific evidence to define the relationship between aggressive periodontitis (AgP) and systemic conditions. The aim of this study was to explore the characteristics of peripheral blood cellular and serum protein parameters in patients with AgP. METHODS Patients with AgP (n = 150) and healthy controls (n = 94) were recruited. Clinical parameters, including probing depth (PD), clinical attachment level (CAL), and percentage of severe sites, were examined. Blood cell variables, including leukocyte, neutrophil, and lymphocyte counts, as well as serum protein parameters, including total protein, albumin, globulin, and albumin/globulin ratio, were analyzed. RESULTS Elevated neutrophil numbers and serum globulin levels were observed in patients with AgP compared to controls (4.22 +/- 1.81 x 10(9)/l versus 3.20 +/- 0.91 x 10(9)/l and 29.20 +/- 3.75 g/l versus 27.17 +/- 3.32 g/l, respectively; P <0.01). Albumin level and albumin/globulin ratio were lower in the AgP group than in the control group (47.65 +/- 2.45 g/l versus 48.88 +/- 2.13 g/l and 1.66 +/- 0.24 versus 1.83 +/- 0.24, respectively; P <0.01). In the AgP group, neutrophil counts and serum globulin levels were positively correlated with clinical parameters, including mean values for PD, CAL, and percentage of severe sites (P <0.05); the albumin level and albumin/globulin ratio were inversely correlated with the clinical parameters as described above (P <0.05). CONCLUSIONS Patients with AgP may have elevated peripheral leukocyte numbers and serum globulin levels as well as decreased serum albumin levels and albumin/globulin ratios compared to controls. These changes might be associated with the severity of periodontal destruction.