A Search for Neurological Mechanisms in Ovulation. 20
A Search for Neurological Mechanisms in Ovulation. 20
复制标题
寻找排卵的神经机制。
DOI：
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发表时间：
1932
期刊：
影响因子：
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通讯作者：
J. E. Markee
中科院分区：
文献类型：
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作者：
J. Hinsey;J. E. Markee
毫无疑问，兔子的神经系统参与了交配后的排卵。这里提出的观察是我们研究这个问题的一个阶段。Ascheim和Zondek发现孕妇尿液中的一种物质（Prolan）产生的作用类似于脑垂体前叶中的性激素。Friedman 2通过静脉注射孕妇尿液诱导兔排卵。这种反应的效用取决于兔子不会自发排卵的事实（Heape， 3 Ancel和Bouin， 4 Hammond和Marshall 5）。我们利用弗里德曼现象让兔子随意排卵。已有证据表明，垂体前叶的prolan和性激素并不相同（Parkes和Hill， 6 Reichert, Pencharz, Simpson， Meyer和Evans， 7 Evans， Meyer和Simpson， 8 Wallen-Lawrence和Van Dyke， 9和Loeb 10）。我们一直在关注是否有任何中枢神经系统的传出通路参与将怀孕尿液注射到兔子体内后的排卵。尽管包括人类在内的许多物种的移植卵巢都发生了排卵（Knauer, 11 Grigorieff, 12 and Frank 13），但这是首次在兔子身上进行的完全不受中枢神经系统影响的卵巢诱导排卵的研究。体重为2至3公斤的初生兔子在单独的笼子中隔离3周。在每个病例中，通过注射8至10毫升孕妇尿液诱导排卵，并在注射后约20小时检查卵巢。在每个实验中都进行了尸检以控制实验过程。
There is no doubt that the nervous system is involved in producing the ovulation which follows copulation in the rabbit. The observations here presented represent one phase of our attack upon this problem. Ascheim and Zondek 1 found that a substance (Prolan) in the urine of pregnant women produces effects similar to the sex hormone in the anterior lobe of the hypophysis. Friedman 2 induced ovulation in the rabbit by the intravenous injection of the urine of pregnant women. The utility of this reaction depends upon the fact that ovulation does not occur spontaneously in the rabbit (Heape, 3 Ancel and Bouin, 4 Hammond and Marshall 5 ). We have utilized the Friedman phenomenon to produce ovulation at will in the rabbit. Evidence has been presented that prolan and the sex hormone from the anterior lobe of the hypophysis are not identical (Parkes and Hill, 6 Reichert, Pencharz, Simpson, Meyer and Evans, 7 Evans, Meyer and Simpson, 8 Wallen-Lawrence and Van Dyke, 9 and Loeb 10 ). We have been concerned in finding out whether or not any of the efferent pathways from the central nervous system are involved in the ovulation that follows the injection of pregnancy urine into the rabbit. Although ovulation has occurred in transplanted ovaries in many species including man (Knauer, 11 Grigorieff, 12 and Frank 13 ), this is the first study in the rabbit of induction of ovulation in ovaries completely isolated from the influence of the central nervous system. Virgin rabbits, weighing 2 to 3 kilos, were isolated in individual cages for 3 weeks. Ovulation was induced in each case by the injection of 8 to 10 cc. of the urine of pregnant women, and the ovaries were examined approximately 20 hours following the injection. An autopsy was done to control the experimental procedures in each of the experiments.