MicroRNAs as novel regulators of angiogenesis.
MicroRNAs as novel regulators of angiogenesis.
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DOI：
10.1161/circresaha.108.191270
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发表时间：
2009-02-27
影响因子：
20.1
通讯作者：
Sessa WC
中科院分区：
文献类型：
--
作者：
Suárez Y;Sessa WC
MicroRNAs是一种短小的非编码RNA，其功能是负向调节基因表达。MiRNAs的转录后调控对发育、动态平衡和疾病的许多方面都很重要。内皮细胞是血管生物学不同方面的关键调节者，包括新血管的形成(血管生成)。在这里，我们综述了miRNAs参与调节血管生成过程的方法和现有的实验证据，以及它们在与异常血管生成相关的血管疾病中的潜在治疗应用。
MicroRNAs are short non-coding RNAs that function as negative regulators of gene expression. Posttranscriptional regulation by miRNAs is important for many aspects of development, homeostasis and disease. Endothelial cells are key regulators of different aspects of vascular biology including the formation of new blood vessels (angiogenesis). Here we review the approaches and current experimental evidence for the involvement of miRNAs in the regulation of the angiogenic process and their potential therapeutic applications for vascular diseases associated with abnormal angiogenesis.