Multi-gradient-echo myelin water fraction imaging: Comparison to the multi-echo-spin-echo technique
Multi-gradient-echo myelin water fraction imaging: Comparison to the multi-echo-spin-echo technique
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DOI：
10.1002/mrm.26809
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发表时间：
2018-03-01
影响因子：
3.3
通讯作者：
Pike, G. Bruce
中科院分区：
文献类型：
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作者：
Alonso-Ortiz, Eva;Levesque, Ives R.;Pike, G. Bruce
目的基于多梯度回波（MGRE）成像的髓磷脂水分数（MWF）标测被提出作为传统多回波自旋回波（MESE）方法的替代方法。在这项工作中，我们进行了比较研究MESE和MGRE衍生MWFs在同一subject group.MethodsMESE和MGRE数据在12名健康志愿者在3 T。T-2* 衰减曲线进行了校正的影响领域的不均匀性和多组分分析的T-2和T-2* 信号进行了使用非负最小二乘fitting.ResultsWhen比较MGRE和MESE-MWFs跨志愿者，没有显着差异之间的平均值观察到在WM，深GM（dGM），和皮质GM（CGM）的（143%），MGRE分别为（6 +/- 2%）和（8 +/- 2%），MESE分别为（13 +/- 2%）、（6 +/- 1%）和（7 +/- 1%）。MGRE和MESE-MWFs显示出很强的相关性（r（2）=0.84），Bland-Altman分析显示MGRE-MWF.ConclusionOverall，我们观察到两种技术之间非常一致。与MESE-MWF相比，MGRE-MWF的小正偏差被认为是其对水交换效应的潜在敏感性降低的结果。这项工作表明，通过仔细校正场不均匀性的影响，MGRE-MWF成像是MESE方法的一个有前途的替代方案。Magn Reson Med 79：1439-1446，2018。(c)2017年国际医学磁共振学会。
PurposeMyelin water fraction (MWF) mapping based on multi-gradient recalled-echo (MGRE) imaging has been proposed as an alternative to the conventional multi-echo-spin-echo (MESE) approach. In this work, we performed a comparative study of MESE and MGRE-derived MWFs in the same subject group.MethodsMESE and MGRE data were acquired in 12 healthy volunteers at 3T. T-2* decay curves were corrected for the effects of field inhomogeneities and multicomponent analysis of T-2 and T-2* signals was performed using non-negative least-squares fitting.ResultsWhen comparing MGRE and MESE-MWFs across volunteers, no significant differences were observed between average values in WM, deep GM (dGM), and cortical GM (cGM) that were (143%), (6 +/- 2%), and (8 +/- 2%) for MGRE, and (13 +/- 2%), (6 +/- 1%), and (7 +/- 1%), respectively, for MESE. The MGRE and MESE-MWFs showed a strong correlation (r(2)=0.84) and Bland-Altman analysis revealed a small positive bias of (0.8 +/- 1.6%) (absolute difference) for the MGRE-MWF.ConclusionOverall, we observed excellent agreement between the two techniques. The small positive bias of the MGRE-MWF is thought to be a consequence of its potentially reduced sensitivity to water exchange effects, compared to the MESE-MWF. This work suggests that with careful correction for the effects of field inhomogeneities, MGRE-MWF imaging is a promising alternative to the MESE approach. Magn Reson Med 79:1439-1446, 2018. (c) 2017 International Society for Magnetic Resonance in Medicine.