Addicted to AA (Acetoacetate): A Point of Convergence between Metabolism and BRAF Signaling.
Addicted to AA (Acetoacetate): A Point of Convergence between Metabolism and BRAF Signaling.
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DOI：
10.1016/j.molcel.2015.07.024
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发表时间：
2015-08
期刊：
影响因子：
16
通讯作者：
S. Trousil;B. Zheng
中科院分区：
文献类型：
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作者：
S. Trousil;B. Zheng
在这个问题上，康等人。（2015）显示致癌BRAFV 600 E刺激生酮酶3-羟基-3-甲基戊二酰-CoA裂解酶的表达，并促进酮体乙酰乙酸的形成，其随后增强BRAFV 600 E/MEK/ERK信号传导。
In this issue Kang et al. (2015) show that oncogenic BRAFV600Estimulates expression of ketogenic enzyme 3-hydroxy-3-methylglutaryl-CoA lyase and promotes the formation of the ketone body acetoacetate, which subsequently enhances BRAFV600E/MEK/ERK signaling.