LOW MORTALITY IN BURNED PATIENTS IN A PSEUDOMONAS VACCINE TRIAL
LOW MORTALITY IN BURNED PATIENTS IN A PSEUDOMONAS VACCINE TRIAL
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假单胞菌疫苗试验中烧伤患者的死亡率较低
DOI：
10.1016/s0140-6736(78)91868-8
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
J. Gupta
中科院分区：
文献类型：
--
作者：
R. J. Jones;E. Roe;J. Gupta
多价假单胞菌疫苗在烧伤患者中的使用来自印度新德里。疫苗含有来自16个国际公认的血清型的表面抗原的提取物。这项试验包括烧伤面积为15%-50%的成人和烧伤面积为5%-30%(全皮肤厚度)的儿童，他们在烧伤后72小时内入院。成人在0、7和14天皮下注射1.0推荐人体剂量(未指明，但基于动物实验)，儿童皮下注射0.5~1.0推荐人类剂量。在0、4、7天和每周采集拭子进行培养，直到出院。入院时，在那些已经定居的人中只发现了11型血清。一些患者在第一周内获得了7、022、2b和12型。43%的患者在某个阶段发现了11型。接种疫苗的受试者获得假单胞菌的速度比对照组慢。结果很有趣。18名接种疫苗的受试者没有死亡记录，而20名未接种疫苗的受试者中至少有8人死亡。受试者轮流进入疫苗接种组和对照组，事实上，接种疫苗组的烧伤面积略大于对照组。[没有提到接种疫苗后的血清学反应]K·C·沃森。
The use of polyvalent pseudomonas vaccine in patients with burns is described from New Delhi, India. The vaccines contained extracts of surface antigens from the 16 internationally recognized serotypes. The trial included adults with 15-50% burns and children with 5-30% burns (full skin thickness), admitted within 72 hours of burning. Adults received 1.0 recommended human doses (not specified but based on animal experiment) and children 0.5 to 1.0 recommended human doses subcutaneously on days 0, 7 and 14. Swabs for culture were taken on days 0, 4, 7 and weekly till discharge. On admission only serotype 11 was found in those already colonized. Types 7, 022, 2b and 12 were acquired by some patients during the first week. Type 11 was found in 43% of patients at some stage. Vaccinated subjects acquired pseudomonas more slowly than the control group.The results are interesting. No deaths were noted in 18 vaccinated subjects whereas no less than 8 of the unvaccinated group of 20 died. Subjects had been admitted alternately to the vaccinated and control groups and in fact the vaccinated group had burns slightly larger than those of the control group. [There is no mention of the serological responses following vaccination.]K. C. Watson.