Abduction of chemokine elements by herpesviruses
Abduction of chemokine elements by herpesviruses
复制标题
DOI：
10.1006/smvy.1997.0146
复制
发表时间：
1998-04-01
期刊：
影响因子：
--
通讯作者：
Schall, TJ
中科院分区：
文献类型：
--
作者：
Dairaghi, DJ;Greaves, DR;Schall, TJ
趋化因子在炎症反应（包括病毒感染）期间协调白细胞募集方面发挥关键作用。趋化因子是可溶性细胞因子，其通过特异性G蛋白偶联的七跨膜受体介导其作用，所述受体在广泛的细胞上表达，包括单核细胞、T细胞、树突细胞和NK细胞。对疱疹病毒基因组的分析表明，这些病毒病原体编码它们自己的趋化因子和趋化因子受体。编码趋化因子元件的病毒基因很可能是从宿主基因组中获得的，并在病毒进化过程中被重塑，以优化功能或获得其细胞同源物未显示的新特性。病毒编码的趋化因子和趋化因子受体是病毒与哺乳动物宿主持续对抗的重要参与者。这些元素的详细表征将提供更好地了解免疫系统如何响应病毒感染，并可能提出新的抗病毒药物靶点和抗病毒治疗的新途径。我们将在这里审查疱疹病毒编码的趋化因子元件，以及它们如何帮助病毒感染和繁殖。(C)北京：科学出版社.
Chemokines play a key role in orchestrating leukocytic recruitment during inflammatory responses, including those to viral infections. Chemokines are soluble cytokines which mediate their effects through specific G protein-coupled, seven-transmembrane receptors which are expressed on a wide range of cells, including monocytes, T-cells, dendritic cells, and NK cells. Analyses of herpesvirus genomes have revealed that these viral pathogens encode their own versions of both chemokines and chemokine receptors. Viral genes encoding chemokine elements were likely to have been acquired from the host genome and have been remodeled during virus evolution to presumably optimize function or acquire new properties not displayed by their cellular homologues. Virus-encoded chemokines and chemokine receptors are important players in the continuing confrontation between viruses and their mammalian hosts. Detailed characterization of these elements will provide a better understanding of how the immune system responds to viral infection and may suggest new antiviral drug targets and new avenues for the development of antiviral therapies. We will review here the chemokine elements encoded by herpesviruses and how they may aid viral infection and propagation. (C) 1998 Academic Press.