Antifungal effect and action mechanism of antimicrobial peptide polybia-CP
Antifungal effect and action mechanism of antimicrobial peptide polybia-CP
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抗菌肽polybia-CP的抗真菌作用及作用机制
DOI：
10.1002/psc.2835
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发表时间：
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影响因子：
2.1
通讯作者：
Rui Wang
中科院分区：
文献类型：
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作者：
Kairong Wang;Fengjing Jia;Wen Dang;Yanyan Zhao;Ranran Zhu;Mengyang Sun;Shuai Qiu;Xiaoping An;Zelin Ma;Yuanyuan Zhu;Jiexi Yan;Ziqing Kong;Rui Wang
近年来，危及生命的侵袭性真菌感染的发病率显著增加。然而，抗真菌治疗选择非常有限。抗菌肽是一类潜在的抗真菌药物的先导化合物。抗微生物肽Polybia-CP是从社会黄蜂Polybia保利斯塔的毒液中纯化的。在这项研究中，我们合成了polybia-CP，并确定了其对一系列的抗真菌作用的阿卡德物种。我们的研究结果表明，Polybia-CP对所测试的真菌细胞具有有效的抗真菌活性和杀真菌活性，并具有所提出的膜活性作用模式。此外，Polybia-CP还可诱导细胞活性氧产生增加，这可能与其抗真菌活性有关。总之，本研究表明，Polybia-CP具有作为抗真菌药物的潜力，或可能为抗真菌治疗选择提供新的策略。版权所有© 2015欧洲肽协会和约翰威利父子有限公司。
The incidence of life‐threatening invasive fungal infections increased significantly in recent years. However, the antifungal therapeutic options are very limited. Antimicrobial peptides are a class of potential lead chemical for the development of novel antifungal agents. Antimicrobial peptide polybia‐CP was purified from the venom of the social waspPolybia paulista. In this study, we synthesized polybia‐CP and determined its antifungal effects against a series of Candidian species. Our results showed that polybia‐CP has potent antifungal activity and fungicidal activity against the tested fungal cells with a proposed membrane‐active action mode. In addition, polybia‐CP could induce the increase of cellular reactive oxygen species production, which would attribute to its antifungal activity. In conclusion, the present study suggests that polybia‐CP has potential as an antifungal agent or may offer a new strategy for antifungal therapeutic option. Copyright © 2015 European Peptide Society and John Wiley & Sons, Ltd.