Efferocytosis Signaling in the Regulation of Macrophage Inflammatory Responses.
Efferocytosis Signaling in the Regulation of Macrophage Inflammatory Responses.
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DOI：
10.4049/jimmunol.1601520
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发表时间：
2017-02-15
期刊：
影响因子：
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通讯作者：
Murphy PS
中科院分区：
文献类型：
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作者：
Elliott MR;Koster KM;Murphy PS
自从Elie Metchnikoff的开创性工作和细胞免疫的发现以来，细胞碎片的吞噬清除一直被认为是解决炎症和恢复受损和感染组织功能的不可或缺的组成部分。我们现在知道，死亡细胞的吞噬清除(胞吐作用)，特别是巨噬细胞和其他免疫吞噬细胞，对炎症组织的先天和获得性免疫反应具有深远的影响。这些免疫调节效应源于巨噬细胞、垂死细胞和其他组织驻留细胞之间的一系列分子信号事件。近年来，许多这些分子通路都是在组织炎症的背景下被识别和研究的，这有助于我们更好地理解泡泡吞噬和炎症之间的关系。我们回顾了可以影响巨噬细胞免疫反应的特定类型的胞吐相关信号，并讨论了它们与炎症相关疾病的相关性。
Since the pioneering work of Elie Metchnikoff and the discovery of cellular immunity, the phagocytic clearance of cellular debris has been considered an integral component of resolving inflammation and restoring function of damaged and infected tissues. We now know that the phagocytic clearance of dying cells (efferocytosis), particularly by macrophages and other immune phagocytes, has profound consequences on innate and adaptive immune responses in inflamed tissues. These immunomodulatory effects result from an array of molecular signaling events between macrophages, dying cells and other tissue-resident cells. In recent years, many of these molecular pathways have been identified and studied in the context of tissue inflammation, helping us better understand the relationship between efferocytosis and inflammation. We review specific types of efferocytosis-related signals that can impact macrophage immune responses and discuss their relevance to inflammation-related diseases.