Molecular analysis of Clostridium difficile strains isolated from 18 cases of recurrent Clostridium difficile-associated diarrhea
Molecular analysis of Clostridium difficile strains isolated from 18 cases of recurrent Clostridium difficile-associated diarrhea
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DOI：
10.1128/jcm.41.7.3413-3414.2003
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发表时间：
2003-07-01
影响因子：
9.4
通讯作者：
Cohen, SH
中科院分区：
文献类型：
--
作者：
Tang-Feldman, Y;Mayo, S;Cohen, SH
难辨梭菌相关性腹泻（CDAD）的复发发生在15 - 20%的患者停止治疗后。采用任意引物PCR方法对18例复发性CDAD患者进行流行病学分析。18例患者中有6例（33.3%）再次感染新毒株，而12例患者在停止治疗后不久复发原毒株。这些数据表明外源性艰难梭菌的再感染是一个常见的问题，并不是所有的复发都是由于复发。
Recurrence of Clostridium difficile-associated diarrhea (CDAD) occurs in 15 to 20% of patients after discontinuation of treatment. Arbitrarily primed PCR was used to investigate the epidemiology of recurrent CDAD in 18 patients. Reinfection with a new strain occurred in 6 of 18 patients (33.3%), while 12 patients relapsed with the original strain shortly after discontinuation of treatment. These data suggest that reinfection with exogenous C. difficile is a common problem and that not all recurrences are due to relapse.