Amygdala volumetry in "imaging-negative" temporal lobe epilepsy
Amygdala volumetry in "imaging-negative" temporal lobe epilepsy
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DOI：
10.1136/jnnp.74.9.1245
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发表时间：
2003-09-01
影响因子：
11
通讯作者：
Cook, MJ
中科院分区：
文献类型：
--
作者：
Bower, SPC;Vogrin, SJ;Cook, MJ
目的：虽然影像阴性的单侧局灶性癫痫患者有时会怀疑杏仁核异常，提示为颞叶癫痫(TLE)，但杏仁核的不对称性在视觉上难以评估。这项研究检查了一组“影像阴性”的TLE患者，估计杏仁核的体积，以确定是否可以检测到隐匿性的杏仁核病变。方法：回顾视频脑电监测数据，发现11名EEG偏侧TLE患者，结构成像正常。结果：11例“影像阴性”患者中有7例杏仁核显著不对称和杏仁核增大，与癫痫的偏侧化相一致。虽然77例HS患者中有35例出现了显著的杏仁核不对称，但这从未归因于同侧杏仁核异常大。与HS患者相比，杏仁核增大的患者发生继发性全身性癫痫发作的可能性较小(p
Objective: Although amygdala abnormalities are sometimes suspected in "imaging-negative" patients with video EEG confirmed unilateral focal epilepsy suggestive of temporal lobe epilepsy (TLE), amygdala asymmetry is difficult to assess visually. This study examined a group of "imaging-negative" TLE patients, estimating amygdala volumes, to determine whether cryptic amygdala lesions might be detected.Methods: Review of video EEG monitoring data yielded 11 patients with EEG lateralised TLE and normal structural imaging. Amygdala volumes were estimated in this group, in 77 patients with pathologically verified hippocampal sclerosis (HS), and in 77 controls.Results: Seven of 11 "imaging-negative" cases had both significant amygdala asymmetry and amygdala enlargement, concordant with seizure lateralisation. Although significant amygdala asymmetry occurred in 35 of 77 HS patients, it was never attributable to an abnormally large ipsilateral amygdala. Compared with patients with HS, patients with amygdala enlargement were less likely to have suffered secondarily generalised seizures (p