Intraocular pressure effects of multiple doses of drugs applied to glaucomatous monkey eyes.
Intraocular pressure effects of multiple doses of drugs applied to glaucomatous monkey eyes.
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DOI：
10.1001/archopht.1987.01060020103038
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发表时间：
1987-02
影响因子：
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通讯作者：
P. Lee;S. Podos;J. Serle;C. Camras;C. Severin
中科院分区：
文献类型：
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作者：
P. Lee;S. Podos;J. Serle;C. Camras;C. Severin
分别在8只食蟹猴眼睛中检测0.5%马来酸噻吗洛尔、2%盐酸肾上腺素、4%盐酸毛果芸香碱、1%钒酸盐、1%毛喉素（非专利名称，colforsin）或0.5%前列腺素F2 α多次给药对眼内压（IOP）的影响，在这些食蟹猴眼睛中，使用氩激光照射小梁网诱导青光眼。在药物治疗前一周，在三天内从上午9：30至下午3：30每小时进行基线IOP测量。一到两天后，开始治疗。将每种药物局部应用于每只猴的双眼，每天两次，持续至少4天。在治疗日和基线日以相同的每小时间隔用校准的气压计测量IOP。将治疗日一天中每个时间的IOP与一天中相应时间测量的平均基线IOP进行比较。局部应用噻吗洛尔、肾上腺素、毛果芸香碱、钒酸盐和前列腺素F2 α可显著降低IOP，治疗过程中无耐受或快速耐受的证据。治疗第二天后，毛喉素未显著降低IOP。
The effects of multiple dosing with 0.5% timolol maleate, 2% epinephrine hydrochloride, 4% pilocarpine hydrochloride, 1% vanadate, 1% forskolin (nonproprietary name, colforsin), or 0.5% prostaglandin F2 alpha on intraocular pressure (IOP) were each tested on eight cynomolgus monkey eyes in which glaucoma was induced by photocoagulating the trabecular meshwork with the argon laser. The week prior to drug therapy, baseline IOP measurements were carried out at hourly intervals from 9:30 am to 3:30 pm on three days. One to two days later, therapy was initiated. Each drug was applied topically to both eyes of each monkey twice daily for at least four days. The IOP was measured with a calibrated pneumatonometer at the same hourly intervals on treatment days as on the baseline days. The IOP at each time of day on treatment days was compared with the average baseline IOP measured at the corresponding time of day. Topical application of timolol, epinephrine, pilocarpine, vanadate, and prostaglandin F2 alpha significantly reduced IOP without evidence of tolerance or tachyphylaxis during the course of therapy. Forskolin did not significantly decrease IOP after the second day of treatment.