Effect of Delayed vs Early Umbilical Cord Clamping on Iron Status and Neurodevelopment at Age 12 Months A Randomized Clinical Trial
Effect of Delayed vs Early Umbilical Cord Clamping on Iron Status and Neurodevelopment at Age 12 Months A Randomized Clinical Trial
复制标题
DOI：
10.1001/jamapediatrics.2013.4639
复制
发表时间：
2014-06-01
期刊：
影响因子：
26.1
通讯作者：
Hellstrom-Westas, Lena
中科院分区：
文献类型：
--
作者：
Andersson, Ola;Domellof, Magnus;Hellstrom-Westas, Lena
预防婴儿期缺铁可促进神经发育。延迟脐带夹紧（DCC）可以防止出生后6个月内缺铁。然而，没有数据可用于长期影响婴儿的结果与时间脐带clamping.Objective.ObjectiveTo调查的影响，DCC相比，早期脐带钳（ECC），对婴儿铁的状态和神经发育在12个月的年龄在欧洲setting.DESIGN，SETTING，在瑞典一家县医院对382名低风险妊娠后出生的足月婴儿进行随机临床试验。随访12个月，包括评价铁状态（铁蛋白水平、转铁蛋白饱和度、转铁蛋白受体水平、网织红细胞血红蛋白水平和平均细胞体积）和父母通过年龄和阶段问卷第二版（ASQ）评估神经发育。
IMPORTANCE Prevention of iron deficiency in infancy may promote neurodevelopment. Delayed cord clamping (DCC) can prevent iron deficiency during the first 6 months of life. However, no data are available on long-term effects on infant outcomes in relation to time for umbilical cord clamping.OBJECTIVE To investigate effects of DCC, as compared with early cord clamping (ECC), on infant iron status and neurodevelopment at age 12 months in a European setting.DESIGN, SETTING, AND PARTICIPANTS Randomized clinical trial of 382 full-term infants born after a low-risk pregnancy at a Swedish county hospital. Follow-up at 12 months included evaluation of iron status (ferritin level, transferrin saturation, transferrin receptor level, reticulocyte hemoglobin level, and mean cell volume) and parental assessment of neurodevelopment by the Ages and Stages Questionnaire, second edition (ASQ).INTERVENTIONS Infants were randomized to DCC (>= 180 seconds after delivery) or ECC (