Effect of vitamin A, vitamin A plus iron and multiple micronutrient-fortified seasoning powder on infectious morbidity of preschool children
Effect of vitamin A, vitamin A plus iron and multiple micronutrient-fortified seasoning powder on infectious morbidity of preschool children
复制标题
DOI：
10.1016/j.nut.2010.04.004
复制
发表时间：
2011-04-01
期刊：
影响因子：
4.4
通讯作者：
Liu, You-xue
中科院分区：
文献类型：
--
作者：
Chen, Ke;Zhang, Xuan;Liu, You-xue
目的：通过对重庆郊区学龄前儿童进行6个月的多种微量营养素强化饮食，改善血红蛋白和血清视黄醇并促进铁储存的动员；中国。我们调查了学龄前儿童饮食中添加多种微量营养素与仅添加维生素 A 和添加维生素 A 加铁的饮食相比是否会导致儿童感染发病率的变化。方法：从 2005 年 12 月至 2006 年 6 月，从三个托儿所招募了 226 名 2 至 6 岁学龄前儿童，随机分配到三个不同的强化饮食组，为期 6 个月。 I 组补充维生素 A；第二组和第三组分别强化维生素A加铁和维生素A加铁、硫胺素、核黄素、叶酸、烟酰胺、锌和钙。在补充期间收集次要功能结果、腹泻和呼吸道感染的发病率。结果：各组在依从性和失访方面具有可比性。有证据表明，与I组和II组儿童相比，III组儿童呼吸道相关疾病、腹泻相关疾病的发生率较低，流鼻涕、咳嗽和发烧症状较少，呼吸道相关疾病和咳嗽持续时间较短。然而，第一组和第二组的儿童之间没有显着或临床上的重要差异。结论：除了一些生化改善之外，对 6 个月内感染发病率的有益影响凸显了这种微量营养素强化调味粉在学龄前儿童饮食中的潜力。 (C) 2011 Elsevier Inc. 保留所有权利：
Objective: Improvement of hemoglobin and serum retinol and facilitation of the mobilization of iron storage were achieved with a multiple-micronutrient-fortified diet in preschoolers for 6 mo in a suburb of Chongqing; China. We investigated whether fortification with multiple micronutrients in a diet for preschool children results in changes in children's infectious morbidity compared with diets fortified solely with vitamin A and with vitamin A plus iron.Methods: From December 2005 to June 2006, 226 2- to 6-y-old preschool children were recruited from three nurseries randomly assigned to three different fortified-diet groups for 6 mo. Group I was fortified with vitamin A; groups II and III were fortified with vitamin A plus iron and vitamin A plus iron, thiamine, riboflavin, folic acid, niacinamide, zinc, and calcium, respectively. The secondary functional outcomes, morbidity of diarrhea and respiratory infection, were collected during supplementation.Results: The groups were comparable concerning compliance and loss to follow-up. There was evidence of a lower incidence rate of respiratory-related illnesses, diarrhea-related illness, fewer symptoms of runny nose, cough, and fever, and shorter duration of respiratory-related illnesses and cough for children in group III compared with children in groups I and II. However, there was no significantly or clinically important difference between children in groups I and II.Conclusion: The beneficial effects on infectious morbidity over 6 mo, in addition to some biochemical improvements, highlight the potential of this micronutrient-fortified seasoning powder supplied in a diet for preschool children. (C) 2011 Elsevier Inc. All rights reserved: